Human Foamy Virus Polypeptides: Identification of Env and Bel Gene Products

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1993 Jun 1

PMID 8388512

Citations 17

Authors

M L Giron

F Rozain

M Canivet

J Peries

Affiliations

Soon will be listed here.

Abstract

Human foamy virus (HFV) proteins were identified in human cells cultured in vitro by immunoprecipitation and immunoblotting with specific antisera. Among several viral polypeptides, four glycoproteins of approximately 160, 130, 70, and 48 kDa were identified in HFV-infected cells. gp130 was shown to represent the intracellular env precursor, and gp70 and gp48 were shown to represent the external and transmembrane env proteins, respectively. The nature of gp160, which shares sequences with the env, bel1, and bel2 proteins, is not yet resolved. In addition, a p62 identified with bel1- and bel2-specific antisera likely corresponds to the bet gene product.

Citing Articles

Intra- and intercellular trafficking of the foamy virus auxiliary bet protein.

Lecellier C, Vermeulen W, Bachelerie F, Giron M, Saib A J Virol. 2002; 76(7):3388-94.

PMID: 11884565 PMC: 136056. DOI: 10.1128/jvi.76.7.3388-3394.2002.

Characterization of the R572T point mutant of a putative cleavage site in human foamy virus Env.

Bansal A, Shaw K, Edwards B, Goepfert P, Mulligan M J Virol. 2000; 74(6):2949-54.

PMID: 10684317 PMC: 111791. DOI: 10.1128/jvi.74.6.2949-2954.2000.

Persistent zoonotic infection of a human with simian foamy virus in the absence of an intact orf-2 accessory gene.

CALLAHAN M, Switzer W, Matthews A, Roberts B, Heneine W, Folks T J Virol. 1999; 73(11):9619-24.

PMID: 10516073 PMC: 112999. DOI: 10.1128/JVI.73.11.9619-9624.1999.

Foamy virus capsids require the cognate envelope protein for particle export.

Pietschmann T, Heinkelein M, Heldmann M, Zentgraf H, Rethwilm A, Lindemann D J Virol. 1999; 73(4):2613-21.

PMID: 10074106 PMC: 104016. DOI: 10.1128/JVI.73.4.2613-2621.1999.

Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease.

Pfrepper K, Rackwitz H, Schnolzer M, Heid H, Lochelt M, Flugel R J Virol. 1998; 72(9):7648-52.

PMID: 9696869 PMC: 110030. DOI: 10.1128/JVI.72.9.7648-7652.1998.

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