Sequence Analysis of Herpes Simplex Virus GB Gene Homologs of Two Platyrrhine Monkey Alpha-herpesviruses

Overview

Journal Arch Virol

Specialty Microbiology

Date 1993 Jan 1

PMID 8385913

Citations 14

Authors

R Eberle

D Black

Affiliations

Soon will be listed here.

Abstract

Homologs of the herpes simplex virus gB gene were identified in two alpha-herpesviruses of platyrrhine monkeys, Herpesvirus saimiri 1 (HVS 1) and H. ateles 1 (HVA 1). These genes were cloned and sequenced in their entirety. Analysis of the predicted amino acid sequences indicated that the gB glycoproteins of these two viruses are of similar size, have 10 Cys residues and 5 potential N-linked glycosylation sites which align exactly with those in other primate alpha-herpesvirus gB polypeptides, and have a similar distribution of predicted secondary structural features, all of which indicate a conserved structure of the gB polypeptide. Alignment of these two gB sequences with those of four other primate alpha-herpesviruses (SA 8, B virus, HSV 1 and HSV 2) revealed localized regions of extensive sequence divergence as well as highly conserved regions. On comparison of the six primate virus gB sequences, the gBs of the two platyrrhine monkey viruses form a subgroup separate from that of the four catarrhine virus gBs. The degree of relatedness of the HVA 1 and HVS 1 gB sequences to each other was equivalent to the degree of relatedness between the human and the cercopithecine monkey virus gB sequences.

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References

Desrosiers R, Falk Jr L . Herpesvirus tamarinus and its relation to herpes simplex virus. J Gen Virol. 1981; 56(Pt 1):119-30. DOI: 10.1099/0022-1317-56-1-119. View

Mou S, Hilliard J, Song C, Eberle R . Comparison of the primate alphaherpesviruses. I. Characterization of two herpesviruses from spider monkeys and squirrel monkeys and viral polypeptides synthesized in infected cells. Arch Virol. 1986; 91(1-2):117-33. DOI: 10.1007/BF01316733. View

Bzik D, Fox B, DeLuca N, Person S . Nucleotide sequence specifying the glycoprotein gene, gB, of herpes simplex virus type 1. Virology. 1984; 133(2):301-14. DOI: 10.1016/0042-6822(84)90397-0. View

Eberle R, Courtney R . Topological distribution of virus-specific and cross-reactive antigenic determinants on the gB glycoprotein of the herpes simplex viruses. J Med Virol. 1989; 27(4):309-16. DOI: 10.1002/jmv.1890270410. View

Eberle R, Hilliard J . Replication of simian herpesvirus SA8 and identification of viral polypeptides in infected cells. J Virol. 1984; 50(2):316-24. PMC: 255623. DOI: 10.1128/JVI.50.2.316-324.1984. View

Barahona H, Melendez L, Melnick J . A compendium of herpesviruses isolated from non-human primates. Intervirology. 1974; 3(3):175-92. DOI: 10.1159/000149754. View

HULL R, DWYER A, Holmes A, Nowakowski E, Deinhardt F, LENNETTE E . Recovery and characterization of a new simian herpesvirus from a fatally infected spider monkey. J Natl Cancer Inst. 1972; 49(1):225-31. View

Kalter S, Weiss S, HEBERLING R, Guajardo J, Smith 3rd G . The isolation of herpesvirus from trigeminal ganglia of normal baboons (Papio cynocephalus). Lab Anim Sci. 1978; 28(6):705-9. View

Marlin S, Highlander S, Holland T, Levine M, Glorioso J . Antigenic variation (mar mutations) in herpes simplex virus glycoprotein B can induce temperature-dependent alterations in gB processing and virus production. J Virol. 1986; 59(1):142-53. PMC: 253049. DOI: 10.1128/JVI.59.1.142-153.1986. View

10.

ZWARTOUW H, BOULTER E . Excretion of B virus in monkeys and evidence of genital infection. Lab Anim. 1984; 18(1):65-70. DOI: 10.1258/002367784780864929. View

11.

Katz D, Hilliard J, Eberle R, Lipper S . ELISA for detection of group-common and virus-specific antibodies in human and simian sera induced by herpes simplex and related simian viruses. J Virol Methods. 1986; 14(2):99-109. DOI: 10.1016/0166-0934(86)90040-6. View

12.

DAVIDSON W, Hummeler K . B virus infection in man. Ann N Y Acad Sci. 1960; 85:970-9. DOI: 10.1111/j.1749-6632.1960.tb50017.x. View

13.

Bzik D, DebRoy C, Fox B, Pederson N, Person S . The nucleotide sequence of the gB glycoprotein gene of HSV-2 and comparison with the corresponding gene of HSV-1. Virology. 1986; 155(2):322-33. DOI: 10.1016/0042-6822(86)90196-0. View

14.

Borchers K, Weigelt W, Buhk H, Ludwig H, Mankertz J . Conserved domains of glycoprotein B (gB) of the monkey virus, simian agent 8, identified by comparison with herpesvirus gBs. J Gen Virol. 1991; 72 ( Pt 9):2299-304. DOI: 10.1099/0022-1317-72-9-2299. View

15.

Killeen A, Harrington L, Wall L, Kelly D . Nucleotide sequence analysis of a homologue of herpes simplex virus type 1 gene US9 found in the genome of simian herpes B virus. J Gen Virol. 1992; 73 ( Pt 1):195-9. DOI: 10.1099/0022-1317-73-1-195. View

16.

McCarthy K, Tosolini F . A review of primate herpes viruses. Proc R Soc Med. 1975; 68(3):145-50. PMC: 1863694. View

17.

Honess R . Herpes simplex and 'the herpes complex': diverse observations and a unifying hypothesis. The eighth Fleming lecture. J Gen Virol. 1984; 65 ( Pt 12):2077-107. DOI: 10.1099/0022-1317-65-12-2077. View

18.

Holmes A, CALDWELL R, Dedmon R, Deinhardt F . ISOLATION AND CHARACTERIZATION OF A NEW HERPES VIRUS. J Immunol. 1964; 92:602-10. View

19.

Hilliard J, Black D, Eberle R . Simian alphaherpesviruses and their relation to the human herpes simplex viruses. Arch Virol. 1989; 109(1-2):83-102. DOI: 10.1007/BF01310520. View

20.

Howard L, Ortlepp S . Construction of cloning/sequencing vectors with an alternative polylinker. Biotechniques. 1989; 7(9):940-2. View