Distinct Functions of SR Proteins in Alternative Pre-mRNA Splicing

Overview

Journal Science

Specialty Science

Date 1993 Apr 9

PMID 8385799

Citations 167

Authors

A M Zahler

K M Neugebauer

W S Lane

M B Roth

Affiliations

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Abstract

Alternative splicing of precursor messenger RNAs (pre-mRNAs) is a common mechanism of regulating gene expression. SR proteins are a family of pre-mRNA splicing factors that are structurally related and evolutionarily conserved. Any member of the SR family can complement a splicing-deficient extract that lacks the entire family of SR proteins. Here it is demonstrated that particular SR proteins have distinct functions in alternative pre-mRNA splicing in vitro. In addition, SR proteins are differentially expressed in a variety of tissues. These results suggest a fundamental role for SR proteins in the regulation of alternative splicing.

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