Novel DNA Polymorphism in the Mouse Tumor Necrosis Factor Receptors Type 1 and Type 2

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1993 Jan 1

PMID 8380565

Citations 5

Authors

S Takao

K Mykytyn

C O Jacob

Affiliations

Soon will be listed here.

Abstract

The introduction of the polymerase chain reaction (PCR) provides an entirely new means of analyzing DNA polymorphism and makes practical the analysis of length variation in simple-sequence tandem repeats of dinucleotides. In the process of cloning and sequencing the mouse genomic DNA for tumor necrosis factor (TNF) receptors type 1 and type 2, we identified two simple dinucleotide repeats within the noncoding regions of TNF receptor type 1 and three such sequences within TNF receptor type 2. PCR analysis of these sequences, using genomic DNA from 21 different inbred and wild mouse strains, as demonstrated by running the amplified products on sequencing gels, showed that the repeats are highly polymorphic. We identified seven alleles of TNF receptor type 2 and five alleles of TNF receptor type 1. Using these polymorphic markers in two sets of recombinant inbred strains of mice, the chromosomal localization of Tnfr-1 was mapped to mouse chromosome 6 and Tnfr-2 was located to the distal portion of mouse chromosome 4.

Citing Articles

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High-resolution mapping of the genes Kcnb3 and Ly63 on distal mouse chromosome 4.

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Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences.

Jacob C, Mykytyn K, Varcony T, Drabkin H Mamm Genome. 1993; 4(8):435-9.

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