Clinical and Cytogenetic Observations During a Six-year Period in an Adult with Fanconi's Anaemia

Overview

Journal Blut

Specialty Hematology

Date 1977 Feb 1

PMID 836967

Citations 12

Authors

T M SCHROEDER

P Drings

P Beilner

G Buchinger

Affiliations

Soon will be listed here.

Abstract

A male adult patient suffering from Fanconi's anemia is described who was diagnosed 5 years before the onset of clinical symptoms by cytogenetic findings of chromosomeinstability in a lymphocyte culture. Repeated clinical, haematological and biochemical investigations of the untreated patient have been made during the observation period of six years. In the same period of time cytogenetic studies have been carried out which show no correlation in results compared with the clinical or physical findings. Four well defined lymphocyte clones have been discovered. The patient is still under observation of the clinic and the cytogenetic department.

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Chromosomal studies of leukemic and preleukemic Fanconii's anemia patients: examples of acquired 'chromosomal amplification.'.

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The identification of fanconi anemia genotypes by clastogenic stress.

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