Radioimmunoscintigraphy with Technetium-99m-labelled Monoclonal Antibody, SM3, in Gynaecological Cancer

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1993 Jun 1

PMID 8339731

Citations 6

Authors

M Granowska

K E Britton

S J Mather

D G Lowe

D Ellison

J Bomanji

J Burchell

J Taylor-Papadimitriou

C R Hudson

J H Shepherd

Affiliations

Soon will be listed here.

Abstract

Radioimmunoscintigraphy (RIS) with technetium-99m labelled SM3, a monoclonal antibody reacting with a polymorphic epithelial mucin glycoprotein core antigen, is evaluated. No adverse effects or thyroid uptake were observed. Studies in 45 patients (one twice) had a sensitivity for gynaecological malignancy of 100% (35/35) and a specificity of 73% (8/11), giving an overall accuracy of 93% (43/46). These results have led to the routine adoption of 99mTc RIS in the management of patients suspected of or having primary or recurrent gynaecological cancer.

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99mTc-labelled SM3 in the preoperative evaluation of axillary lymph nodes and primary breast cancer with change detection statistical processing as an aid to tumour detection.

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Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody.

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Peroperative radioimmunodetection of ovarian carcinoma using a hand-held gamma detection probe.

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PMID: 7981086 PMC: 2033666. DOI: 10.1038/bjc.1994.484.

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