Expression of Intercellular Adhesion Molecule (ICAM)-1 by a Subset of Astrocytes in Alzheimer Disease and Some Other Degenerative Neurological Disorders

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1993 Jan 1

PMID 8337942

Citations 42

Authors

H Akiyama

T Kawamata

T Yamada

I Tooyama

T Ishii

P L McGeer

Affiliations

Soon will be listed here.

Abstract

Intercellular adhesion molecule-1 (ICAM-1) was localized immunohistochemically in postmortem brain tissue of Alzheimer's disease (AD), progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, and controls. In controls, only capillaries were stained for ICAM-1. In affected areas of neurologically diseased brains, a subset of reactive astrocytes was also strongly stained. In addition, there were irregular, diffuse patches of positive staining in the tissue matrix. In AD, many of these patches had dense cores which corresponded with senile plaques. Double immunostaining for glial fibrillary acidic protein and ICAM-1 indicated that some reactive astrocytes at the periphery of senile plaques were positive for ICAM-1. Within such plaques, microglial aggregates were stained intensely for leukocyte function-associated antigen-1 (LFA-1), the adhesion molecule for ICAM-1. The LFA-1/ICAM-1 system appears to play an important role in the interaction of astrocytes and microglia in several neurological diseases.

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References

Frohman E, Frohman T, Dustin M, Vayuvegula B, Choi B, Gupta A . The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation. J Neuroimmunol. 1989; 23(2):117-24. DOI: 10.1016/0165-5728(89)90030-1. View

Sobel R, Mitchell M, Fondren G . Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol. 1990; 136(6):1309-16. PMC: 1877574. View

Osborn L . Leukocyte adhesion to endothelium in inflammation. Cell. 1990; 62(1):3-6. DOI: 10.1016/0092-8674(90)90230-c. View

Hildreth J, Gotch F, Hildreth P, McMichael A . A human lymphocyte-associated antigen involved in cell-mediated lympholysis. Eur J Immunol. 1983; 13(3):202-8. DOI: 10.1002/eji.1830130305. View

Raine C, Cannella B, Duijvestijn A, Cross A . Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab Invest. 1990; 63(4):476-89. View

Akiyama H, McGeer P . Brain microglia constitutively express beta-2 integrins. J Neuroimmunol. 1990; 30(1):81-93. DOI: 10.1016/0165-5728(90)90055-r. View

Springer T, Lasky L . Cell adhesion. Sticky sugars for selectins. Nature. 1991; 349(6306):196-7. DOI: 10.1038/349196a0. View

Schwarting R, STEIN H, Wang C . The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia. Blood. 1985; 65(4):974-83. View

Frohman E, Frohman T, Gupta S, de Fougerolles A, Van Den Noort S . Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease. J Neurol Sci. 1991; 106(1):105-11. DOI: 10.1016/0022-510x(91)90202-i. View

10.

Satoh J, Kim S, Kastrukoff L, Takei F . Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes. J Neurosci Res. 1991; 29(1):1-12. DOI: 10.1002/jnr.490290102. View

11.

Yamada T, Akiyama H, McGeer P . Complement-activated oligodendroglia: a new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d. Neurosci Lett. 1990; 112(2-3):161-6. DOI: 10.1016/0304-3940(90)90196-g. View

12.

Dunn S, Hillam A, Stomski F, Jin B, Lucas C, Boyd A . Leukocyte adhesion molecules involved in inflammation. Transplant Proc. 1989; 21(1 Pt 1):31-4. View

13.

Rossler K, Neuchrist C, Kitz K, Scheiner O, Kraft D, Lassmann H . Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB). J Neurosci Res. 1992; 31(2):365-74. DOI: 10.1002/jnr.490310219. View

14.

Altieri D . Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion. J Immunol. 1991; 147(6):1891-8. View

15.

Seth R, RAYMOND F, Makgoba M . Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet. 1991; 338(8759):83-4. DOI: 10.1016/0140-6736(91)90077-3. View

16.

Patarroyo M, Prieto J, Rincon J, Timonen T, Lundberg C, Lindbom L . Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology. Immunol Rev. 1990; 114:67-108. DOI: 10.1111/j.1600-065x.1990.tb00562.x. View

17.

ONeill J, Butter C, Baker D, Gschmeissner S, Kraal G, Butcher E . Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse. Immunology. 1991; 72(4):520-5. PMC: 1384371. View

18.

Patarroyo M, Prieto J, Beatty P, Clark E, Gahmberg C . Adhesion-mediating molecules of human monocytes. Cell Immunol. 1988; 113(2):278-89. DOI: 10.1016/0008-8749(88)90027-5. View

19.

Rozemuller J, Eikelenboom P, Pals S, STAM F . Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family. Neurosci Lett. 1989; 101(3):288-92. DOI: 10.1016/0304-3940(89)90547-8. View

20.

McGeer P, Akiyama H, Itagaki S, McGeer E . Immune system response in Alzheimer's disease. Can J Neurol Sci. 1989; 16(4 Suppl):516-27. DOI: 10.1017/s0317167100029863. View