Energy Metabolism in Muscle Paresis and Recovery Studied by 31P-MR Spectroscopy: a Case Report

Overview

Journal Ital J Neurol Sci

Specialty Neurology

Date 1993 Apr 1

PMID 8314681

Authors

R Funicello

B Barbiroli

P Zaniol

P Martinelli

Affiliations

Soon will be listed here.

Abstract

We report a 31P Magnetic Resonance Spectroscopy (31P-MRS) study on the changes of energy metabolism in human leg anterior and lateral compartment muscles with paresis due to compression from a herniated lumbar disc at the L4-L5 level and recovery to normality. A low phosphocreatine to inorganic phosphate ratio due to both decreased phosphocreatine and increased inorganic phosphate contents and a normal intracellular pH were the features of muscles with paresis. Changes of 31P-MRS parameters were followed during 18 weeks of treatment with physical therapy until complete recovery. Results show that 31P-MRS is a useful clinical tool for detecting even small biochemical changes that may occur in muscles and for checking the effects of therapy.

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