Septicaemia in Patients with and Without AIDS at Westminster Hospital, London

The types of organism causing septicaemia in patients with AIDS and without AIDS at Westminster Hospital were examined prospectively over a period of 2 years (1990-1991). Altogether 417 episodes of septicaemia were diagnosed, 148 (35%) of which were in patients with AIDS. Of septicaemias in patients with AIDS, 53 (36%) were caused by mycobacteria. Non-mycobacterial septicaemias were associated with IV access devices in 58 (61%) of patients with AIDS and in 50 (19%) of those without AIDS. Gram-negative organisms were responsible for septicaemia associated with IV access devices in 16 (28%) of 58 patients with AIDS and in 8 (16%) of 50 patients without AIDS. Non-typhoidal Salmonella species or Shigella species caused 13 (31%) of 42 episodes of septicaemia caused by Gram-negative organisms in patients with AIDS. These findings have influenced the strategy for empirical therapy of septicaemia in patients with AIDS at Westminster Hospital.