Lymphocyte Response in Vitro to Plasmodium Falciparum Merozoite Antigens in Donors from a Holoendemic Area

Overview

Journal Parasitol Res

Specialty Parasitology

Date 1993 Jan 1

PMID 8295898

Citations 2

Authors

A Dieye

H G HEIDRICH

C Rogier

J F Trape

P Launois

A A Holder

J L Sarthou

Affiliations

Soon will be listed here.

Abstract

Crude merozoite antigens from Plasmodium falciparum were used to evaluate the proliferative response of peripheral mononuclear cells (PBMCs) from 114 inhabitants of the village of Dielmo (Senegal, West Africa) exposed continuously to malaria transmission. The high or low responses to merozoite antigens obtained in lymphocyte stimulation assays were correlated with the presence or absence of parasites, IFN-gamma production and HLA phenotype. The high responders produced high levels of IFN-gamma, in contrast to the low responders, most of whom did not secrete IFN-gamma (23/27). Among others, the two HLA phenotypes HLA-B51 and HLA-DR1 were significantly associated with a high response (P < 0.05).

Citing Articles

Immune responses to Plasmodium falciparum-merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119.

Garraud O, Diouf A, Holm I, Perraut R, Longacre S Immunology. 1999; 97(3):497-505.

PMID: 10447773 PMC: 2326866. DOI: 10.1046/j.1365-2567.1999.00804.x.

Secretion of parasite-specific immunoglobulin G by purified blood B lymphocytes from immune individuals after in vitro stimulation with recombinant Plasmodium falciparum merozoite surface protein-119 antigen.

Garraud O, Diouf A, Holm I, Nguer C, Spiegel A, Perraut R Immunology. 1999; 97(2):204-10.

PMID: 10447733 PMC: 2326825. DOI: 10.1046/j.1365-2567.1999.00763.x.

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