Metacarpophalangeal Pattern Profile Analysis in Brachmann-de Lange Syndrome

Overview

Journal Am J Med Genet

Specialty Genetics

Date 1993 Nov 15

PMID 8291512

Citations 2

Authors

M G Butler

G A Dahir

D D Gale

F J Meaney

Affiliations

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Abstract

We analyzed the metacarpophalangeal pattern profile (MCPP) of 19 individuals with Brachmann-de Lange syndrome (BDLS) and calculated a mean syndrome profile. Fourteen of 19 individuals with BDLS had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with BDLS compared with a sample of normal individuals produced a correct classification rate of 100% based on a function of 2 MCPP variables that may provide a useful tool for assisting in the diagnosis of BDLS. An average pattern variability index calculated for the BDLS patients was 1.9 indicating an abnormal hand pattern in this syndrome.

Citing Articles

Metacarpophalangeal pattern profile analysis in Noonan syndrome.

Butler M, Kumar R, Davis M, Gale D, Dahir G, Meaney F Am J Med Genet. 2000; 92(2):128-31.

PMID: 10797437 PMC: 6777554.

SPONASTRIME dysplasia: report of an 11-year-old boy and review of the literature.

COOPER H, Crowe J, Butler M Am J Med Genet. 2000; 92(1):33-9.

PMID: 10797420 PMC: 5237388. DOI: 10.1002/(sici)1096-8628(20000501)92:1<33::aid-ajmg6>3.0.co;2-u.

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