Genetic Heterogeneity of Hepatocellular Carcinoma

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Jan 18

PMID 8290606

Citations 39

Authors

H Unsal

C Yakicier

C Marcais

M Kew

M Volkmann

H Zentgraf

K J Isselbacher

M Ozturk

Affiliations

Soon will be listed here.

Abstract

We studied 80 hepatocellular carcinomas from three continents for p53 gene (TP53) mutations and hepatitis B virus (HBV) sequences. p53 mutations were frequent in tumors from Mozambique but not in tumors from South Africa, China, and Germany. Independent of geographic origin, most tumors were positive for HBV sequences. X gene coding sequences of HBV were detected in 78% of tumors, whereas viral sequences in the surface antigen- and core antigen-encoding regions were present in less than 45% of tumors. These observations indicate that hepatocellular carcinomas are genetically heterogeneous. Mozambican-type of hepatocellular carcinomas are characterized by a high incidence of p53 mutations related to aflatoxins. In other tumors, the rarity of p53 mutations combined with the frequent presence of viral X gene coding sequences suggests a possible interference of HBV with the wild-type p53 function.

Citing Articles

Genetic Variants in p53 Pathway Genes Affect Survival of Patients with HBV-Related Hepatocellular Carcinoma.

Qin L, Qiu M, Tang J, Liu S, Lin Q, Huang Q J Hepatocell Carcinoma. 2024; 11:1541-1555.

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Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma.

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Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center.

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Rotimi S, Rotimi O, Salhia B JCO Glob Oncol. 2021; 7:747-755.

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Investigation of gene mutations and expression in hepatocellular carcinoma and cirrhosis in association with hepatitis B virus infection.

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