Ultrastructural Localization of Urease of Helicobacter Pylori

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 1993 Nov 1

PMID 8283959

Citations 14

Authors

G Bode

P Malfertheiner

G Lehnhardt

M Nilius

H DITSCHUNEIT

Affiliations

Soon will be listed here.

Abstract

Helicobacter pylori urease was characterized by means of an enzyme histochemical electron microscopic technique. Ultrastructural analysis revealed no urease activity in one strain; in seven H. pylori strains (43.75%), urease activity was associated with the cell membrane. Eight strains (50.0%) showed reaction product located within the cytoplasm. Urease activity showed no correlation with localization of activity. Our results demonstrate that H. pylori urease is not uniform in all H. pylori strains, and differences in activity and localization of urease activity may account for different virulence activities.

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