Haemorrhage-induced Production of Fos in Neurons of the Lamina Terminalis: Role of Endogenous Angiotensin II

Overview

Journal Neurosci Lett

Specialty Neurology

Date 1993 Sep 3

PMID 8264959

Citations 3

Authors

E Badoer

B J Oldfield

M J McKinley

Affiliations

Soon will be listed here.

Abstract

Hypotensive haemorrhage increased the production of Fos, a marker of cell activation, in cells of the subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT) as well as in the supraoptic (SON) and paraventricular (PVN) nuclei in conscious rats. Pretreatment with captopril (100 mg/kg i.p.) inhibited the production of Fos in cells of the SFO and OVLT but did not reduce the concentration of Fos-positive cell nuclei in the PVN and SON. The results suggest that the production of Fos in the SFO and OVLT induced by the haemorrhage is probably due to elevated levels of circulating angiotensin II.

Citing Articles

Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose.

Wu L, Mao C, Liu Y, Shi A, Xu F, Zhang L Peptides. 2010; 32(1):104-11.

PMID: 20965221 PMC: 3010528. DOI: 10.1016/j.peptides.2010.10.012.

Electrophysiological and morphological properties of pre-autonomic neurones in the rat hypothalamic paraventricular nucleus.

Stern J J Physiol. 2001; 537(Pt 1):161-77.

PMID: 11711570 PMC: 2278924. DOI: 10.1111/j.1469-7793.2001.0161k.x.

Cyclophosphamide cystitis as a model of visceral pain in rats: minor effects at mesodiencephalic levels as revealed by the expression of c-fos, with a note on Krox-24.

Bon K, Lanteri-Minet M, De Pommery J, Michiels J, Menetrey D Exp Brain Res. 1997; 113(2):249-64.

PMID: 9063711 DOI: 10.1007/BF02450323.