Intravascular Lymphomatosis: a Clinicopathological Study of Three Cases

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1994 Jan 1

PMID 8263013

Citations 4

Authors

U Liszka

M Drlicek

P Hitzenberger

E MACHACEK

H Mayer

G Stockhammer

W Grisold

Affiliations

Soon will be listed here.

Abstract

In patients with intravascular lymphomatosis (IL) a broad spectrum of neuro-psychiatric disorders including dementia, focal neurological signs and seizures has been reported. Clinical diagnosis is difficult since neuroimaging findings are nonspecific. The clinical histories, biopsy and autopsy findings of three patients with IL, one with brain biopsy, are described. Two of them presented with rapidly progressive, fluctuating dementia. The third patient suffered from seizures followed by aphasia. Histology revealed large-cell lymphoma of the B cell type. The prognosis of IL, in general, is poor.

Citing Articles

Status epilepticus as the initial presentation of intravascular lymphoma.

Hiraga A, Ozaki D, Kamitsukasa I, Araki N, Arai K Case Rep Neurol. 2012; 4(2):107-12.

PMID: 22807906 PMC: 3398095. DOI: 10.1159/000339815.

Intravascular lymphoma: magnetic resonance imaging correlates of disease dynamics within the central nervous system.

Baehring J, Henchcliffe C, Ledezma C, Fulbright R, Hochberg F J Neurol Neurosurg Psychiatry. 2005; 76(4):540-4.

PMID: 15774442 PMC: 1739607. DOI: 10.1136/jnnp.2003.033662.

Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.

Albrecht R, Krebs B, Reusche E, Nagel M, Lencer R, Kretzschmar H Eur Arch Psychiatry Clin Neurosci. 2004; 255(4):232-5.

PMID: 15565300 DOI: 10.1007/s00406-004-0551-9.

Angiotropic large cell lymphoma with imaging characteristics of CNS vasculitis.

Song D, Boulis N, McKeever P, Quint D AJNR Am J Neuroradiol. 2002; 23(2):239-42.

PMID: 11847048 PMC: 7975247.

References

Theaker J, Gatter K, Esiri M, Easterbrook P . Neoplastic angioendotheliosis--further evidence supporting a lymphoid origin. Histopathology. 1986; 10(12):1261-70. DOI: 10.1111/j.1365-2559.1986.tb02569.x. View

Keahey T, Guerry 4th D, Tuthill R, Bondi E . Malignant angioendotheliomatosis proliferans treated with doxorubicin. Arch Dermatol. 1982; 118(7):512-4. View

Wick M, Mills S, Scheithauer B, Cooper P, Davitz M, Parkinson K . Reassessment of malignant "angioendotheliomatosis". Evidence in favor of its reclassification as "intravascular lymphomatosis". Am J Surg Pathol. 1986; 10(2):112-23. View

Domizio P, Hall P, Cotter F, Amiel S, Tucker J, Besser G . Angiotropic large cell lymphoma (ALCL): morphological, immunohistochemical and genotypic studies with analysis of previous reports. Hematol Oncol. 1989; 7(3):195-206. DOI: 10.1002/hon.2900070303. View

Neuwelt E, Frenkel E, Gumerlock M, Braziel R, DANA B, Hill S . Developments in the diagnosis and treatment of primary CNS lymphoma. A prospective series. Cancer. 1986; 58(8):1609-20. DOI: 10.1002/1097-0142(19861015)58:8<1609::aid-cncr2820580805>3.0.co;2-7. View

Hochberg F, Miller D . Primary central nervous system lymphoma. J Neurosurg. 1988; 68(6):835-53. DOI: 10.3171/jns.1988.68.6.0835. View

Clark W, DOHAN Jr F, Moss T, Schweitzer J . Immunocytochemical evidence of lymphocytic derivation of neoplastic cells in malignant angioendotheliomatosis. J Neurosurg. 1991; 74(5):757-62. DOI: 10.3171/jns.1991.74.5.0757. View

Stroup R, Sheibani K, Moncada A, Purdy L, Battifora H . Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations. Cancer. 1990; 66(8):1781-8. DOI: 10.1002/1097-0142(19901015)66:8<1781::aid-cncr2820660824>3.0.co;2-5. View

Ansbacher L, Low N, Beck D, Boarini D, Jacoby C, Cancilla P . Neoplastic angioendotheliosis: a clinicopathological entity with multifocal presentation. Case report. J Neurosurg. 1981; 54(3):412-5. DOI: 10.3171/jns.1981.54.3.0412. View

10.

Croisile B, Tommasi M, Jouvet A, Truffert A, TRILLET M, AIMARD G . [Large-cell intravascular malignant lymphoma]. Rev Neurol (Paris). 1990; 146(3):184-90. View

11.

Willemze R, Kruyswijk M, DE BRUIN C, Meijer C, Van Berkel W . Angiotropic (intravascular) large cell lymphoma of the skin previously classified as malignant angioendotheliomatosis. Br J Dermatol. 1987; 116(3):393-9. DOI: 10.1111/j.1365-2133.1987.tb05854.x. View

12.

DeAngelis L, Yahalom J, Heinemann M, Cirrincione C, Thaler H, Krol G . Primary CNS lymphoma: combined treatment with chemotherapy and radiotherapy. Neurology. 1990; 40(1):80-6. DOI: 10.1212/wnl.40.1.80. View

13.

Wrotnowski U, Mills S, Cooper P . Malignant angioendotheliomatosis. An angiotropic lymphoma?. Am J Clin Pathol. 1985; 83(2):244-8. DOI: 10.1093/ajcp/83.2.244. View

14.

Abe S, Shimbo Y, Saito T, Kohno M, Nishiyama A, Kumanishi T . An immunohistochemical study on "neoplastic angioendotheliosis": demonstration of B lymphocyte markers in the neoplastic cells. Acta Neuropathol. 1988; 75(3):313-6. DOI: 10.1007/BF00690540. View

15.

Drlicek M, Grisold W, Liszka U, Hitzenberger P, MACHACEK E . Angiotropic lymphoma (malignant angioendotheliomatosis) presenting with rapidly progressive dementia. Acta Neuropathol. 1991; 82(6):533-5. DOI: 10.1007/BF00293391. View

16.

Sheibani K, Battifora H, Winberg C, Burke J, ELLINGER G, Quigley N . Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma. N Engl J Med. 1986; 314(15):943-8. DOI: 10.1056/NEJM198604103141502. View

17.

Hamada K, Hamada T, Satoh M, Tashiro K, Katoh I, Naganuma M . Two cases of neoplastic angioendotheliomatosis presenting with myelopathy. Neurology. 1991; 41(7):1139-40. DOI: 10.1212/wnl.41.7.1139. View

18.

Bloomfield C, Arthur D, Frizzera G, Levine E, Peterson B . Nonrandom chromosome abnormalities in lymphoma. Cancer Res. 1983; 43(6):2975-84. View

19.

Otrakji C, Voigt W, Amador A, Nadji M, Gregorios J . Malignant angioendotheliomatosis--a true lymphoma: a case of intravascular malignant lymphomatosis studied by southern blot hybridization analysis. Hum Pathol. 1988; 19(4):475-8. DOI: 10.1016/s0046-8177(88)80500-8. View

20.

Sheibani K, Kendrick F, Winberg C, Rappaport H . Angiotropic large cell lymphoma of the prostate gland: an immunohistochemical study. Hum Pathol. 1986; 17(9):964-7. DOI: 10.1016/s0046-8177(86)80648-7. View