Alpha-chain Disease with Localized Plasmacytoma of the Intestine. Immunoperoxidase Study

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1976 Jul 1

PMID 825335

Citations 6

Authors

J M Skinner

O N Manousos

J Economidou

A Nicolaou

G MERIKAS

Affiliations

Soon will be listed here.

Abstract

An ileocaecal tumour in a patient with alpha-chain disease in remission was studied immunohistochemically by a quantitive immunoperoxidase method. The tumour which was histologically shown to be a plasmacytoma consisted of 68% alpha cells and 15% lambda cells; no kappa cells were found. Away from the tumour the pattern of immunoglobulin-producing cells was normal. It is concluded that the abnormal cell causing alpha-chain disease remains inactive and that the patient developed a plasmacytoma from a different cell clone.

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