Inhibition of Tumor Cell Invasion in the Boyden Chamber Assay by a Mannosidase Inhibitor, Mannostatin A

Overview

Journal Anticancer Res

Specialty Oncology

Date 1993 Sep 1

PMID 8239514

Citations 6

Authors

Y Ochi

S Atsumi

T Aoyagi

K Umezawa

Affiliations

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Abstract

An alpha-mannosidase inhibitor, mannostatin A, from Streptoverticillium verticillus var. quintum inhibited chemotactic invasion of mouse B16/F10 melanoma cells in the Boyden chamber assay. It also inhibited in vitro invasion of K-ras-NIH3T3 cells. Mannostatin A did not inhibit the growth of either cell line at the concentration effective to inhibit invasion. Addition of mannostatin A to the cultured B16/F10 or K-ras-NIH3T3 cells inhibited cellular alpha-mannoside activity specifically. Mannostatin A-treated B16/F10 cells also showed decreased metastatic activity in vivo in C57Bl/6 mice.

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