Granulocytic Sarcoma (chloroma) Causing Spinal Cord Compression

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 1993 Jan 1

PMID 8232876

Citations 9

Authors

B J Frohna

D J Quint

Affiliations

Soon will be listed here.

Abstract

Granulocytic sarcoma (chloroma) is a rare solid tumor of myelogenous stem cells, usually appearing in patients with acute myelogenous leukemia and less commonly in patients with chronic myelogenous leukemia or myeloproliferative disorders. We present a spinal epidural granulocytic sarcoma causing thoracic spinal cord compression in a patient with chronic anemia secondary to myelofibrosis.

Citing Articles

Chloroma - A Rare Case of Metastatic Tumor to Dorsal Spine in Patient of Chronic Myeloid Leukemia Causing Acute Paraparesis.

Nair V, Kundnani V, Shetty A, Jain M, Chodavadiya S, Patel J J Orthop Case Rep. 2023; 13(2):30-33.

PMID: 37144072 PMC: 10152944. DOI: 10.13107/jocr.2023.v13.i02.3544.

Epidural myeloid sarcoma as the presenting symptom of chronic myeloid leukemia blast crisis.

Slouma M, Rahmouni S, Dhahri R, Khayati Y, Zriba S, Amorri W Clin Rheumatol. 2020; 39(8):2453-2459.

PMID: 32458246 DOI: 10.1007/s10067-020-05167-4.

Granulocytic sarcoma presenting as presenting as monoparesis: A rare case report.

Gupta A, Chanduka A, Sundar I, Verma J, Chopra S Asian J Neurosurg. 2015; 9(4):241.

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Myelofibrosis-associated complications: pathogenesis, clinical manifestations, and effects on outcomes.

Mughal T, Vaddi K, Sarlis N, Verstovsek S Int J Gen Med. 2014; 7:89-101.

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Acute myeloid leukaemia presenting as faecal incontinence.

Lim H, Cho Y, Jang P, Kim H, Jang H BMJ Case Rep. 2011; 2009.

PMID: 21686339 PMC: 3028031. DOI: 10.1136/bcr.12.2008.1397.

References

Barnett M, ZUSSMAN W . Granulocytic sarcoma of the brain: a case report and review of the literature. Radiology. 1986; 160(1):223-5. DOI: 10.1148/radiology.160.1.3459211. View

Barton J, CONRAD M, Poon M . Pseudochloroma: extramedullary hematopoietic nodules in chronic myelogenous leukemia. Ann Intern Med. 1979; 91(5):735-8. DOI: 10.7326/0003-4819-91-5-735. View

NEIMAN R, Barcos M, Berard C, Bonner H, Mann R, RYDELL R . Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer. 1981; 48(6):1426-37. DOI: 10.1002/1097-0142(19810915)48:6<1426::aid-cncr2820480626>3.0.co;2-g. View

Kellie S, Waters K . Extradural chloroma with spinal compression--an unusual presentation of acute myelogenous leukemia. Aust N Z J Med. 1984; 14(2):160-2. DOI: 10.1111/j.1445-5994.1984.tb04281.x. View

Cohen R, Segall H, Nelson Jr M, Zee C, Ahmadi J . Bilateral retroorbital chloromas in a 16-month-old child: CT features. J Comput Assist Tomogr. 1988; 12(5):895-6. View

Hassoun H, LANGEVIN Jr E, Lathi E, PALEK J . Spinal cord compression secondary to extramedullary hematopoiesis: a noninvasive management based on MRI. Am J Hematol. 1991; 37(3):201-3. DOI: 10.1002/ajh.2830370314. View

Singounas E, Sakas D, Hadley D, Chalevelakis G, Sfakianos G, Raptis S . Paraplegia in a pregnant thalassemic woman due to extramedullary hematopoiesis: successful management with transfusions. Surg Neurol. 1991; 36(3):210-5. DOI: 10.1016/0090-3019(91)90115-p. View

Kaufmann T, Coleman M, Giardina P, Nisce L . The role of radiation therapy in the management of hematopoietic neurologic complications in thalassemia. Acta Haematol. 1991; 85(3):156-9. DOI: 10.1159/000204880. View

Liu P, Ishimaru T, McGregor D, Okada H, Steer A . Autopsy study of granulocytic sarcoma (chloroma) in patients with myelogenous leukemia, Hiroshima-Nagasaki 1949-1969. Cancer. 1973; 31(4):948-55. DOI: 10.1002/1097-0142(197304)31:4<948::aid-cncr2820310428>3.0.co;2-n. View

10.

Pomeranz S, Hawkins H, Towbin R, Lisberg W, Clark R . Granulocytic sarcoma (chloroma): CT manifestations. Radiology. 1985; 155(1):167-70. DOI: 10.1148/radiology.155.1.3856292. View

11.

Kao S, Yuh W, Sato Y, Barloon T . Intracranial granulocytic sarcoma (chloroma): MR findings. J Comput Assist Tomogr. 1987; 11(6):938-41. DOI: 10.1097/00004728-198711000-00003. View

12.

Mann K, Yue C, Chan K, Ma L, Ngan H . Paraplegia due to extramedullary hematopoiesis in thalassemia. Case report. J Neurosurg. 1987; 66(6):938-40. DOI: 10.3171/jns.1987.66.6.0938. View

13.

Dunnick N, Heaston D . Computed tomography of extracranial chloroma. J Comput Assist Tomogr. 1982; 6(1):83-5. DOI: 10.1097/00004728-198202000-00013. View

14.

Wang A, Lin J, Power T, Haykal H, Zamani A . Chloroma of cerebellum, tentorium and occipital bone in acute myelogenous leukemia. Neuroradiology. 1987; 29(6):590. DOI: 10.1007/BF00350453. View

15.

Woo E, Yue C, Mann K, Ngan H . Intracerebral chloromas: unusual computed tomography appearance of leukemic infiltration. J Comput Tomogr. 1986; 10(4):365-7. DOI: 10.1016/0149-936x(86)90033-0. View

16.

Wong M, Krol G, Rosenblum M . Occult epidural chloroma complicated by acute paraplegia following lumbar puncture. Ann Neurol. 1992; 31(1):110-2. DOI: 10.1002/ana.410310121. View

17.

Jackson Jr D, Randall M, Richards 2nd F . Spinal cord compression due to extramedullary hematopoiesis in thalassemia: long-term follow-up after radiotherapy. Surg Neurol. 1988; 29(5):389-92. DOI: 10.1016/0090-3019(88)90047-x. View

18.

Leonard K, Mamourian A . MR appearance of intracranial chloromas. AJNR Am J Neuroradiol. 1989; 10(5 Suppl):S67-8. PMC: 8333958. View

19.

Nickels J, Koivuniemi A, HEISKANEN O . Granulocytic sarcoma (chloroma) of the cerebellum and meninges a case report. Acta Neurochir (Wien). 1979; 46(3-4):297-301. DOI: 10.1007/BF01430592. View

20.

Stork J, Cigtay O, Schellinger D, Jacobson R . Recurrent chloromas in acute myelogenous leukemia. AJR Am J Roentgenol. 1984; 142(4):777-8. DOI: 10.2214/ajr.142.4.777. View