Molecular and Biochemical Features of Poly (ADP-ribose) Metabolism

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 1993 May 26

PMID 8232248

Citations 64

Authors

D Lautier

J Lagueux

J Thibodeau

L Menard

G G Poirier

Affiliations

Soon will be listed here.

Abstract

In the past five years, poly(ADP-ribosyl)ation has developed greatly with the help of molecular biology and the improvement of biochemical techniques. In this article, we describe the physico-chemical properties of the enzymes responsible for the synthesis and degradation of poly(ADP-ribose), respectively poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase. We then discuss the possible roles of this polymer in DNA repair and replication as well as in cellular differentiation and transformation. Finally, we put forward various hypotheses in order to better define the function of this polymer found only in eucaryotes.

Citing Articles

Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions.

Medrano M, Contreras M, Caballero-Velazquez T, Martinez L, Bejarano-Garcia J, Calderon-Ruiz R Br J Cancer. 2024; 130(9):1529-1541.

PMID: 38461169 PMC: 11058274. DOI: 10.1038/s41416-024-02618-6.

PARP-1: a critical regulator in radioprotection and radiotherapy-mechanisms, challenges, and therapeutic opportunities.

Li W, Wang F, Song G, Yu Q, Du R, Xu P Front Pharmacol. 2023; 14:1198948.

PMID: 37351512 PMC: 10283042. DOI: 10.3389/fphar.2023.1198948.

PARP-1 Is a Potential Marker of Retinal Photooxidation and a Key Signal Regulator in Retinal Light Injury.

Li X, Zhang Z, Fan B, Li Y, Song D, Li G Oxid Med Cell Longev. 2022; 2022:6881322.

PMID: 36124087 PMC: 9482536. DOI: 10.1155/2022/6881322.

Opinion: PARP inhibitors in cancer-what do we still need to know?.

Wicks A, Krastev D, Pettitt S, Tutt A, Lord C Open Biol. 2022; 12(7):220118.

PMID: 35892198 PMC: 9326299. DOI: 10.1098/rsob.220118.

Emerging role of PARP-1 and PARthanatos in ischemic stroke.

Liu S, Luo W, Wang Y J Neurochem. 2021; 160(1):74-87.

PMID: 34241907 PMC: 9010225. DOI: 10.1111/jnc.15464.

References

Hunting D, Gowans B, HENDERSON J . Specificity of inhibitors of poly(ADP-ribose) synthesis. Effects on nucleotide metabolism in cultured cells. Mol Pharmacol. 1985; 28(2):200-6. View

Cohen J, Catino D, Petzold S, Berger N . Activation of poly(adenosine diphosphate ribose) polymerase by SV 40 minichromosomes: effects of deoxyribonucleic acid damage and histone H1. Biochemistry. 1982; 21(20):4931-40. DOI: 10.1021/bi00263a016. View

Scovassi A, Izzo R, Franchi E, Bertazzoni U . Structural analysis of poly(ADP-ribose)polymerase in higher and lower eukaryotes. Eur J Biochem. 1986; 159(1):77-84. DOI: 10.1111/j.1432-1033.1986.tb09835.x. View

Herzog H, Zabel B, Schneider R, Auer B, Hirsch-Kauffmann M, Schweiger M . Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli. Proc Natl Acad Sci U S A. 1989; 86(10):3514-8. PMC: 287168. DOI: 10.1073/pnas.86.10.3514. View

Borek C, Morgan W, Ong A, Cleaver J . Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis. Proc Natl Acad Sci U S A. 1984; 81(1):243-7. PMC: 344648. DOI: 10.1073/pnas.81.1.243. View

de Murcia G, Huletsky A, Poirier G . Modulation of chromatin structure by poly(ADP-ribosyl)ation. Biochem Cell Biol. 1988; 66(6):626-35. DOI: 10.1139/o88-072. View

de Murcia G, Huletsky A, Lamarre D, Gaudreau A, POUYET J, Daune M . Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation. J Biol Chem. 1986; 261(15):7011-7. View

Althaus F, Lawrence S, He Y, Sattler G, Tsukada Y, Pitot H . Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes. Nature. 1982; 300(5890):366-8. DOI: 10.1038/300366a0. View

Jonsson G, Jacobson E, Jacobson M . Mechanism of alteration of poly(adenosine diphosphate-ribose) metabolism by hyperthermia. Cancer Res. 1988; 48(15):4233-9. View

10.

Yamagoe S, Kohda T, Oishi M . Poly(ADP-ribose) polymerase inhibitors suppress UV-induced human immunodeficiency virus type 1 gene expression at the posttranscriptional level. Mol Cell Biol. 1991; 11(7):3522-7. PMC: 361090. DOI: 10.1128/mcb.11.7.3522-3527.1991. View

11.

Borek C, Cleaver J . Antagonistic action of a tumor promoter and a poly(adenosine diphosphoribose) synthesis inhibitor in radiation-induced transformation in vitro. Biochem Biophys Res Commun. 1986; 134(3):1334-41. DOI: 10.1016/0006-291x(86)90396-7. View

12.

. 3'-Deoxy-NAD+ as a substrate for poly(ADP-ribose)polymerase and the reaction mechanism of poly(ADP-ribose) elongation. J Biol Chem. 1988; 263(33):17690-6. View

13.

Lonn U, Lonn S . Accumulation of 10-kilobase DNA replication intermediates in cells treated with 3-aminobenzamide. Proc Natl Acad Sci U S A. 1985; 82(1):104-8. PMC: 396980. DOI: 10.1073/pnas.82.1.104. View

14.

Yoshihara K, Itaya A, Tanaka Y, Ohashi Y, Ito K, Teraoka H . Inhibition of DNA polymerase alpha, DNA polymerase beta, terminal deoxynucleotidyl transferase, and DNA ligase II by poly(ADP-ribosyl)ation reaction in vitro. Biochem Biophys Res Commun. 1985; 128(1):61-7. DOI: 10.1016/0006-291x(85)91644-4. View

15.

Wielckens K, George E, Pless T, Hilz H . Stimulation of poly(ADP-ribosyl)ation during Ehrlich ascites tumor cell "starvation" and suppression of concomitant DNA fragmentation by benzamide. J Biol Chem. 1983; 258(7):4098-104. View

16.

Levi V, Jacobson M, Jacobson E . Simultaneous determination of linear and branched residues in poly(ADP-ribose). Anal Biochem. 1983; 131(2):410-8. DOI: 10.1016/0003-2697(83)90192-6. View

17.

Tanuma S, Endo H . Purification and characterization of an (ADP-ribose)n glycohydrolase from human erythrocytes. Eur J Biochem. 1990; 191(1):57-63. DOI: 10.1111/j.1432-1033.1990.tb19093.x. View

18.

Herendeen D, Kassavetis G, Barry J, Alberts B, Geiduschek E . Enhancement of bacteriophage T4 late transcription by components of the T4 DNA replication apparatus. Science. 1989; 245(4921):952-8. DOI: 10.1126/science.2672335. View

19.

Brennan R, Matthews B . The helix-turn-helix DNA binding motif. J Biol Chem. 1989; 264(4):1903-6. View

20.

Ebisuzaki K, Casley W, Griffiths A, Wheaton L . Temporal mapping of the differentiation pathway of the murine erythroleukemia cell. Cancer Res. 1991; 51(6):1668-73. View