[Pathogenesis of Neurofibromatosis. Light- and Electron Microscopical Investigations (author's Transl)]

Overview

Journal Arch Dermatol Res (1975)

Specialty Dermatology

Date 1976 Jul 26

PMID 822788

Citations 3

Authors

H Heine

G Schaeg

T NASEMANN

Affiliations

Soon will be listed here.

Abstract

Light- and electron microscopical investigations of the pathogenesis of Recklinghausen's neurofibromatosis can support those views which consider the Schwanncells in these tumors to develop from mesenchymal cells, that means from reticular fibroblasts. It seems to be of special interest that these cells while transforming to Schwann cells become successive coated with a glycocalyx (surface coat); The whirle-or onion skin like formation of the tumor cells lead to a splitting of the ground substance into numerous compartments accompanied by a change in ground substance composition. This obviously cohere with an increasing number of mast cells within the tumor. It may be that these arrangements of the tumor tissue plays an important part in tumor growth. With this, the great importance of a regular composition of the extracellular matrix and cell surface coats for an undisturbed flow of information from cell to cell is discussed.

Citing Articles

[Ultrastructural investigations on the pathogenesis of hyperplasias and tumors of skin connective tissue (author's transl)].

Heine H, Schaeg G Arch Dermatol Res (1975). 1976; 257(1):67-77.

PMID: 1008606 DOI: 10.1007/BF00569115.

[Light- and electron microscopical investigation on the pathogenesis of Kaposi's sarcoma (author's transl)].

Heine H, Schaeg G, NASEMANN T Arch Dermatol Res (1975). 1977; 258(2):175-84.

PMID: 869580 DOI: 10.1007/BF00561623.

Different types of benign nerve sheath tumors. Light microscopy, electron microscopy and autoradiography.

Lassmann H, Jurecka W, LASSMANN G, Gebhart W, MATRAS H, Watzek G Virchows Arch A Pathol Anat Histol. 1977; 375(3):197-210.

PMID: 143775 DOI: 10.1007/BF01102988.

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