The Fate of Newly Formed Satellite Cells During Compensatory Muscle Hypertrophy

Overview

Journal Virchows Arch B Cell Pathol

Specialties Cell Biology
Pathology

Date 1976 Aug 11

PMID 822576

Citations 36

Authors

S Schiaffino

S P Bormioli

M Aloisi

Affiliations

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Abstract

Compensatory hypertrophy was induced in the rat extensor digitorum longus muscle by extirpation of the synergistic tibialis anterior. Injections of 3H-thymidine (2 muCi/g body weight) was given at 24, 48, and 72 h after the operation. In animals killed immediately after the last injection both satellite cell nuclei and true muscle nuclei were labeled, whereas in animals killed 4 weeks later only true muscle nuclei were labeled. The results are interpreted as indicating incorporation of newly formed satellite cells into the fibers during compensatory hypertrophy.

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