Luminol and Lucigenin As Detectors for O2.-

Overview

Journal Free Radic Biol Med

Specialties Biochemistry
Biology
General Medicine

Date 1993 Oct 1

PMID 8225026

Citations 65

Authors

K Faulkner

I Fridovich

Affiliations

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Abstract

Univalent oxidation of luminol and univalent reduction of lucigenin must precede reaction with O2.- if that reaction is to lead to luminescence. The assumption that luminol or lucigenin, per se, reacts with O2.- in a way leading to luminescence is incorrect, and leads to misinterpretation of results. The chemical reactions leading to the O2(.-)-dependent luminescences of luminol and of lucigenin are discussed.

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