Mapping the Uroporphyrinogen Decarboxylase, Coproporphyrinogen Oxidase and Ferrochelatase Loci in Bacillus Subtilis

Overview

Journal Mol Gen Genet

Specialties Genetics
Molecular Biology

Date 1976 Jul 5

PMID 822275

Citations 7

Authors

A Miczak

I Berek

G IVANOVICS

Affiliations

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Abstract

Three genes hemE, hemF, hemG taking part in the porphyrin biosynthesis of Baccillus subtilis were mapped by two- and three-factor transduction crosses. The gene hemE determines uroporphyrinogen decarboxylase (EC 4.1.1.37) the gene hemF coproporphyrinogen oxidase (EC 1.3.3.3) and the gene hemG ferrochelatase (EC 4.99.1.1) enzymes. The loci hemE, hemF, hemG, are not linked to hemA locus and located near the argC and metD loci.

Citing Articles

In vivo and in vitro studies of Bacillus subtilis ferrochelatase mutants suggest substrate channeling in the heme biosynthesis pathway.

Olsson U, Billberg A, Sjovall S, Al-Karadaghi S, Hansson M J Bacteriol. 2002; 184(14):4018-24.

PMID: 12081974 PMC: 135158. DOI: 10.1128/JB.184.14.4018-4024.2002.

Bacillus subtilis HemY is a peripheral membrane protein essential for protoheme IX synthesis which can oxidize coproporphyrinogen III and protoporphyrinogen IX.

Hansson M, Hederstedt L J Bacteriol. 1994; 176(19):5962-70.

PMID: 7928957 PMC: 196813. DOI: 10.1128/jb.176.19.5962-5970.1994.

The Bacillus subtilis chromosome.

Henner D, Hoch J Microbiol Rev. 1980; 44(1):57-82.

PMID: 6774224 PMC: 373234. DOI: 10.1128/mr.44.1.57-82.1980.

Revised genetic linkage map of Bacillus subtilis.

Piggot P, Hoch J Microbiol Rev. 1985; 49(2):158-79.

PMID: 2989674 PMC: 373028. DOI: 10.1128/mr.49.2.158-179.1985.

Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.

Hansson M, Hederstedt L J Bacteriol. 1992; 174(24):8081-93.

PMID: 1459957 PMC: 207547. DOI: 10.1128/jb.174.24.8081-8093.1992.

References

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