Reversal of Diastolic Dysfunction by Intravenous Magnesium Chloride

Overview

Journal Can J Cardiol

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 1993 Sep 1

PMID 8221360

Citations 3

Authors

F Kraus

Affiliations

Soon will be listed here.

Abstract

Objective: To treat diastolic dysfunction in patients with coronary artery disease (CAD).

Design: Open study of the intravenous injection of 5 mL of a solution containing 17% magnesium chloride (equal to 100 mg of elemental magnesium) during routine coronary angiography in patients with a raised left ventricular end-diastolic pressure (LVEDP).

Setting: A hospital department of cardiac hemodynamics.

Subjects: Ten patients with angiographically documented CAD.

Results: After magnesium chloride injection, the LVEDP was significantly reduced in all patients, from a mean of 24 +/- 3 to 16 +/- 3 mmHg (P < 0.001).

Conclusions: Under the short term conditions of the study, the injection of magnesium chloride effectively improved left ventricular diastolic function. Further study of the long term effect is required.

Citing Articles

Relationship Between Dietary Magnesium Intake and Incident Heart Failure Among Older Women: The WHI.

Wu W, Huang M, Taveira T, Roberts M, Martin L, Wellenius G J Am Heart Assoc. 2020; 9(7):e013570.

PMID: 32192409 PMC: 7428611. DOI: 10.1161/JAHA.119.013570.

Relation of Magnesium Intake With Cardiac Function and Heart Failure Hospitalizations in Black Adults: The Jackson Heart Study.

Taveira T, Ouellette D, Gulum A, Choudhary G, Eaton C, Liu S Circ Heart Fail. 2016; 9(4):e002698.

PMID: 27056880 PMC: 4826717. DOI: 10.1161/CIRCHEARTFAILURE.115.002698.

Nesiritide for treatment of perioperative low cardiac output syndromes in cardiac surgical patients: an initial experience.

Gordon G, Schumann R, Rastegar H, Khabbaz K, England M J Anesth. 2006; 20(4):307-11.

PMID: 17072697 DOI: 10.1007/s00540-006-0430-9.