Osmotic Blood-brain Barrier Disruption: CT and Radionuclide Imaging

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 1994 Mar 1

PMID 8197962

Citations 11

Authors

D A Clunie

J Stevens

R Hogan

J Monard

F Ramsey

E A Neuwelt

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare CT and radionuclide imaging of osmotic blood-brain barrier disruption. To develop a quantitative method for imaging osmotic blood-brain barrier disruption and to see if iopamidol could be safely given intravenously in conjunction with blood-brain barrier disruption.

Methods: Forty-five blood-brain barrier disruption procedures were imaged with CT and radionuclide scans. The scans were evaluated with visual and quantitative scales. Patients were observed for adverse effects after blood-brain barrier disruption.

Results: There was a 4% rate of seizures in this study. There was good agreement between visual CT and radionuclide grading systems. Quantitative methods to grade disruption did not add useful information to visual interpretations.

Conclusions: Nonionic iodine-based contrast medium has a lower incidence of seizures when injected intravenously in conjunction with osmotic blood-brain barrier disruption than ionic contrast material. Contrast-enhanced CT is the preferred method to image disruption because it has better spatial resolution than radionuclide techniques.

Citing Articles

Safety of intra-arterial chemotherapy with or without osmotic blood-brain barrier disruption for the treatment of patients with brain tumors.

Uluc K, Ambady P, McIntyre M, Tabb J, Kersch C, Nerison C Neurooncol Adv. 2022; 4(1):vdac104.

PMID: 35892048 PMC: 9307096. DOI: 10.1093/noajnl/vdac104.

Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.

Jia Y, Zhang L, Liu Z, Mao C, Ma Z, Li W Cell Discov. 2022; 8(1):21.

PMID: 35228523 PMC: 8885854. DOI: 10.1038/s41421-021-00363-1.

Brain Mechanisms of COVID-19-Sleep Disorders.

Semyachkina-Glushkovskaya O, Mamedova A, Vinnik V, Klimova M, Saranceva E, Ageev V Int J Mol Sci. 2021; 22(13).

PMID: 34203143 PMC: 8268116. DOI: 10.3390/ijms22136917.

Real-time monitoring of human blood-brain barrier disruption.

Kiviniemi V, Korhonen V, Kortelainen J, Rytky S, Keinanen T, Tuovinen T PLoS One. 2017; 12(3):e0174072.

PMID: 28319185 PMC: 5358768. DOI: 10.1371/journal.pone.0174072.

Improving the clinical management of traumatic brain injury through the pharmacokinetic modeling of peripheral blood biomarkers.

Dadas A, Washington J, Marchi N, Janigro D Fluids Barriers CNS. 2016; 13(1):21.

PMID: 27903281 PMC: 5402680. DOI: 10.1186/s12987-016-0045-y.