A Case of Acute Monocytic Leukemia with T(11;17) Involving a Rearrangement of MLL-1 and a Region Proximal to the RARA Gene

Overview

Journal Cancer Genet Cytogenet

Date 1994 May 1

PMID 8194047

Citations 2

Authors

B R Reeves

H Kempski

K Jani

J Borrow

K Howe

E Solomon

L Kearney

F Cotter

Affiliations

Soon will be listed here.

Abstract

A case of acute monocytic leukemia with t(11;17)(123;q11-21) arising in a 4-month-old boy is described. The breakpoint on chromosome 11 could be mapped to an 8-kb BamHI fragment within the MLL-1 gene, as seen in the majority of infant leukemias. In situ hybridization with cosmid probes allowed us to map the breakpoint on 17q proximal to the RARA gene, while Southern and Northern analyses showed that the gene was not disrupted by the translocation.

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