A Non-productive Subacute Sclerosing Panencephalitis (SSPE) Virus of Human and Ferret: an Ultrastructural Study

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1976 Apr 26

PMID 818871

Citations 8

Authors

H R Brown

H Thormar

Affiliations

Soon will be listed here.

Abstract

A non-productive syncytiogenic measles virus isolated from the brain of an SSPE patient was grown on Vero cells. The ultrastructure of the infected syncytia was studied by electron microscopic and immunoperoxidase techniques. It was compared with the isolate of the virus after passage in ferrets, the Edmonston strain of wild measles virus and the Halle productive strain of SSPE, all on Vero cells. The immunoperoxidase labeling of the cell membranes of the Edmonston measles virus infected cells was very heavy and uniform. In contrast, the labeling of the non-productive SSPE infected cells was clearly discontinuous. In the latter, there was a preponderance of intranuclear over cytoplasmic nucleocapsid formation, whereas cytoplasmic nucleocapsids were prevalent in the virion-producing strains. Many similarities between Vero cells infected with the wild measles virus and the Halle strain of SSPE were observed, although differences between this SSPE strain and strains reported by others were noted.

Citing Articles

Immunolabeling of SSPE and wild-type measles viruses in ferret brain cell culture.

Brown H, Thormar H, Lin F Acta Neuropathol. 1980; 50(3):181-6.

PMID: 6998252 DOI: 10.1007/BF00688751.

Characterization of a hamster brain cell line persistently infected with measles virus.

Vainionpaa R, Salmi A, Arstila P Arch Virol. 1982; 71(4):311-22.

PMID: 6178387 DOI: 10.1007/BF01315061.

Fuzzy material surrounding measles virus nucleocapsids identified as matrix protein. Brief report.

Brown H, Goller N, Thormar H, Norrby E Arch Virol. 1987; 94(1-2):163-8.

PMID: 3579607 DOI: 10.1007/BF01313735.

Measles virus matrix protein gene expression in a subacute sclerosing panencephalitis patient brain and virus isolate demonstrated by cDNA hybridization and immunocytochemistry.

Brown H, Goller N, Thormar H, Rudelli R, Tourtellotte W, Shapshak P Acta Neuropathol. 1987; 75(2):123-30.

PMID: 3324622 DOI: 10.1007/BF00687072.

Ultrastructural and biochemical findings in brain cell cultures infected with canine distemper virus.

Glaus T, Griot C, Richard A, ALTHAUS U, HERSCHKOWITZ N, Vandevelde M Acta Neuropathol. 1990; 80(1):59-67.

PMID: 2360417 DOI: 10.1007/BF00294222.

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