Effect of Antimicrobial and Antineoplastic Drugs on the Uptake of Fluconazole by Human Neutrophils and Tissue Culture Cells

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 1993 Dec 1

PMID 8187791

Authors

I Garcia

A Pascual

C Conejo

J Salvador

E J Perea

Affiliations

Soon will be listed here.

Abstract

The effect of eight antimicrobial and three antineoplastic drugs on the uptake of fluconazole by human neutrophils and culture epithelial cells was evaluated. Fluconazole reached higher concentrations intracellularly than extracellularly (cellular to extracellular concentration ratio C/E > or = 1.3) in the presence of therapeutical concentrations of the antimicrobial and antineoplastic agents evaluated.

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