Antigen Presentation by Macrophages from Bacille Calmette-Guérin (BCG)-resistant and -susceptible Mice

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1994 May 1

PMID 8187331

Authors

M E Hilburger

B S Zwilling

Affiliations

Soon will be listed here.

Abstract

We have compared the antigen-presenting capacity of macrophages from congenic BALB/c.Bcgr and BALB/c.Bcgs mice that differentially express MHC class II glycoproteins. Several different criteria were used to evaluate the presentation of a protein antigen, ovalbumin (OVA), including limiting the concentration of antigen or the numbers of macrophages, and using both native OVA and OVA peptide 323-339. No differences in the capacity of macrophages from Bcgr and Bcgs mice to present antigen to a OVA-specific T cell hybridoma were found. Splenic macrophages from BCG-infected congenic mice also induced an equivalent amount of IL-2 production by the T cell hybridoma. The relationship of these findings to other differences that have been attributed to Bcg are discussed.

References

Kappler J, Skidmore B, White J, Marrack P . Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J Exp Med. 1981; 153(5):1198-214. PMC: 2186156. DOI: 10.1084/jem.153.5.1198. View

Vidal S, Malo D, Vogan K, Skamene E, Gros P . Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell. 1993; 73(3):469-85. DOI: 10.1016/0092-8674(93)90135-d. View

Shimonkevitz R, Colon S, Kappler J, Marrack P, Grey H . Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J Immunol. 1984; 133(4):2067-74. View

Hoffenbach A, Lagrange P, Bach M . Strain variation of lymphokine production and specific antibody secretion in mice infected with Mycobacterium lepraemurium. Cell Immunol. 1985; 91(1):1-11. DOI: 10.1016/0008-8749(85)90026-7. View

Johnson S, Zwilling B . Continuous expression of I-A antigen by peritoneal macrophages from mice resistant to Mycobacterium bovis (strain BCG). J Leukoc Biol. 1985; 38(5):635-47. DOI: 10.1002/jlb.38.5.635. View

Zwilling B, Vespa L, MASSIE M . Regulation of I-A expression by murine peritoneal macrophages: differences linked to the Bcg gene. J Immunol. 1987; 138(5):1372-6. View

Bahr G, Chedid L, Behbehani K . Induction, in vivo and in vitro, of macrophage membrane interleukin-1 by adjuvant-active synthetic muramyl peptides. Cell Immunol. 1987; 107(2):443-54. DOI: 10.1016/0008-8749(87)90251-6. View

Denis M, Forget A, Pelletier M, Skamene E . Pleiotropic effects of the Bcg gene. I. Antigen presentation in genetically susceptible and resistant congenic mouse strains. J Immunol. 1988; 140(7):2395-400. View

Brett S, Butler R . Macrophage activity in resistant and susceptible mouse strains infected with Mycobacterium lepraemurium. Immunology. 1988; 63(4):701-6. PMC: 1454777. View

10.

Kaye P, Patel N, Blackwell J . Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function. Immunology. 1988; 65(1):17-22. PMC: 1385013. View

11.

Denis M, Buschman E, Forget A, Pelletier M, Skamene E . Pleiotropic effects of the Bcg gene. II. Genetic restriction of responses to mitogens and allogeneic targets. J Immunol. 1988; 141(11):3988-93. View

12.

Denis M, Forget A, Pelletier M, Skamene E . Pleiotropic effects of the Bcg gene: III. Respiratory burst in Bcg-congenic macrophages. Clin Exp Immunol. 1988; 73(3):370-5. PMC: 1541763. View

13.

Vespa L, Zwilling B . Expression of I-A by macrophages from Bcgr and Bcgs mice. Transient expression of I-A is due to degradation of MHC class II glycoproteins. J Immunol. 1989; 143(1):214-20. View

14.

Balkwill F, Burke F . The cytokine network. Immunol Today. 1989; 10(9):299-304. DOI: 10.1016/0167-5699(89)90085-6. View

15.

Appelberg R, Sarmento A . The role of macrophage activation and of Bcg-encoded macrophage function(s) in the control of Mycobacterium avium infection in mice. Clin Exp Immunol. 1990; 80(3):324-31. PMC: 1535191. DOI: 10.1111/j.1365-2249.1990.tb03288.x. View

16.

Harding C, UNANUE E . Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature. 1990; 346(6284):574-6. DOI: 10.1038/346574a0. View

17.

Demotz S, Grey H, Sette A . The minimal number of class II MHC-antigen complexes needed for T cell activation. Science. 1990; 249(4972):1028-30. DOI: 10.1126/science.2118680. View

18.

Freedman A, Freeman G, Rhynhart K, Nadler L . Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol. 1991; 137(2):429-37. DOI: 10.1016/0008-8749(91)90091-o. View

19.

Roach T, Kiderlen A, Blackwell J . Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains. Infect Immun. 1991; 59(11):3935-44. PMC: 258980. DOI: 10.1128/iai.59.11.3935-3944.1991. View

20.

Blackwell J, Roach T, Atkinson S, Ajioka J, Barton C, Shaw M . Genetic regulation of macrophage priming/activation: the Lsh gene story. Immunol Lett. 1991; 30(2):241-8. DOI: 10.1016/0165-2478(91)90032-6. View