Can Adenine Nucleotides Predict Primary Nonfunction of the Human Liver Homograft?

Overview

Journal Transpl Int

Specialty General Surgery

Date 1994 Jan 1

PMID 8179809

Citations 13

Authors

I Hamamoto

S Takaya

S Todo

O Bronsther

S Fujita

T M van Gulik

K Nakamura

W Irish

T E Starzl

Affiliations

Soon will be listed here.

Abstract

Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction. AN, PC, and nicotinamide adenine dinucleotide, oxidized form (NAD+) of the tissue before (pretransplant) and after graft reperfusion (post-transplant) and of the effluent were analyzed. The graft outcome was classified into two groups (group A: successful, n = 64; group B: primary nonfunctioning, n = 4). No significant differences were observed in pretransplant measurements between groups A and B, whereas ATP, ADP, total AN, total AN + total PC (T) and NAD+, in post-transplant tissues, were significantly higher in group A. Xanthine in the effluent was significantly higher in group B than in group A. ATP, ADP, total AN, T, and NAD+ in post-transplant tissue were significantly associated with primary graft nonfunction by logistic regression analysis.

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