Metastatic Malignant Melanoma with Spontaneous and Complete Regression of the Primary Lesion. Case Report and Review of the Literature

Background: Spontaneous regression of malignant melanoma is characterized by a partial or complete disappearance of the neoplasm. Partial regression of melanoma has been documented in large series, but complete regression is reported as occurring only sporadically.

Objective: To describe a case of metastatic malignant melanoma where the primary lesion underwent spontaneous and complete regression and to review the literature pertaining to regression of melanoma.

Methods: The patient was examined clinically. Wide excision of the skin with the lesion was performed as well as left inguinal lymph node dissection.

Results: Histologic examination of the lesion revealed complete regression of malignant melanoma. Examination of the lymph node dissected from the adjacent inguinal area revealed matastatic melanoma.

Conclusions: Greater attention should be devoted to identification of regression in melanoma, clinically and histologically, evaluating the prognostic implications which regression might indicate.