Phospholipases and Protein Kinases During Phagocyte Activation

Phospholipases and protein kinases are critical for the intracellular transmission and amplification of signals induced by extracellular ligands. Chemotactic activation of phagocytes through G protein coupled receptors leads to inflammatory responses of the immune cells. Downstream of G proteins, phospholipases generate precursors for eicosanoid synthesis and are involved in the functional responses. Recently, the molecular characterization of specific enzymes of the signalling cascades has gained much attention in research.