Streptococcus Uberis Resists the Bactericidal Action of Bovine Neutrophils Despite the Presence of Bound Immunoglobulin

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1994 May 1

PMID 8168949

Citations 9

Authors

J A Leigh

T R Field

Affiliations

Soon will be listed here.

Abstract

Streptococcus uberis 0140J was more resistant to the bactericidal action of bovine neutrophils after growth in chemically defined medium (CDM) supplemented with casein hydrolysate than when grown in CDM alone. Neither adult bovine serum obtained prior to vaccination nor hyperimmune serum raised against this bacterium was capable of acting as an effective opsonin towards S. uberis grown in the presence of casein hydrolysate. There was no detectable difference in the ability of bacteria grown in either CDM or CDM supplemented with casein hydrolysate to bind immunoglobulin G1 (IgG1), IgG2, or IgM from either hyperimmune serum or preparations of immunoglobulin from the same serum. Bacteria of both the phagocytosis-resistant and phagocytosis-sensitive phenotypes presented the same amount of IgG2 Fc terminus on their surfaces. It is concluded that the inducible resistance of S. uberis to bactericidal action of bovine neutrophils is not mediated by inhibition of antibody binding.

Citing Articles

A Paradox in Bacterial Pathogenesis: Activation of the Local Macrophage Inflammasome Is Required for Virulence of .

Archer N, Egan S, Coffey T, Emes R, Addis M, Ward P Pathogens. 2020; 9(12).

PMID: 33260788 PMC: 7768481. DOI: 10.3390/pathogens9120997.

Streptococcus uberis-specific T cells are present in mammary gland secretions of cows and can be activated to kill S. uberis.

Denis M, Lacy-Hulbert S, Buddle B, Williamson J, Wedlock D Vet Res Commun. 2011; 35(3):145-56.

PMID: 21279814 DOI: 10.1007/s11259-011-9462-1.

Use of molecular epidemiology in veterinary practice.

Zadoks R, Schukken Y Vet Clin North Am Food Anim Pract. 2006; 22(1):229-61.

PMID: 16517304 PMC: 7126525. DOI: 10.1016/j.cvfa.2005.11.005.

First insights into the evolution of Streptococcus uberis: a multilocus sequence typing scheme that enables investigation of its population biology.

Coffey T, Pullinger G, Urwin R, Jolley K, Wilson S, Maiden M Appl Environ Microbiol. 2006; 72(2):1420-8.

PMID: 16461695 PMC: 1392973. DOI: 10.1128/AEM.72.2.1420-1428.2006.

Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis.

Segura M, Gottschalk M, Olivier M Infect Immun. 2004; 72(9):5322-30.

PMID: 15322029 PMC: 517481. DOI: 10.1128/IAI.72.9.5322-5330.2004.

References

Kronvall G, Williams Jr R . Differences in anti-protein A activity among IgG subgroups. J Immunol. 1969; 103(4):828-33. View

Hirsch J, BERNHEIMER A, Weissmann G . MOTION PICTURE STUDY OF THE TOXIC ACTION OF STREPTOLYSINS ON LEUCOCYTES. J Exp Med. 1963; 118:223-8. PMC: 2137707. DOI: 10.1084/jem.118.2.223. View

SCHALM O, LASMANIS J, Jain N . Conversion of chronic staphylococcal mastitis to acute gangrenous mastitis after neutropenia in blood and bone marrow produced by an equine anti-bovine leukocyte serum. Am J Vet Res. 1976; 37(8):885-90. View

HILL A, Shears A, Hibbitt K . The elimination of serum-resistant Escherichia coli from experimentally infected single mammary glands of healthy cows. Res Vet Sci. 1978; 25(1):89-93. View

Schalen C, Christensen P, GRUBB R . Lancefield extract of group A streptococci type 15 acts like an anti-human IgG with restricted specificity. Acta Pathol Microbiol Scand C. 1978; 86(1):41-3. DOI: 10.1111/j.1699-0463.1978.tb02556.x. View

LASCELLES A . The immune system on the ruminant mammary gland and its role in the control of mastitis. J Dairy Sci. 1979; 62(1):154-67. DOI: 10.3168/jds.s0022-0302(79)83216-6. View

Horwitz M, Silverstein S . Influence of the Escherichia coli capsule on complement fixation and on phagocytosis and killing by human phagocytes. J Clin Invest. 1980; 65(1):82-94. PMC: 371342. DOI: 10.1172/JCI109663. View

BISNO A . Alternate complement pathway activation by group A streptococci: role of M-protein. Infect Immun. 1979; 26(3):1172-6. PMC: 414743. DOI: 10.1128/iai.26.3.1172-1176.1979. View

Manjula B, Fischetti V . Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule. J Exp Med. 1980; 151(3):695-708. PMC: 2185799. DOI: 10.1084/jem.151.3.695. View

10.

Howard C, Taylor G, Brownlie J . Surface receptors for immunoglobulin on bovine polymorphonuclear neutrophils and macrophages. Res Vet Sci. 1980; 29(1):128-30. View

11.

King B, Wilkinson B . Binding of human immunoglobulin G to protein A in encapsulated Staphylococcus aureus. Infect Immun. 1981; 33(3):666-72. PMC: 350759. DOI: 10.1128/iai.33.3.666-672.1981. View

12.

Williams M, HILL A . A role for IgM in the in vitro opsonisation of Staphylococcus aureus and Escherichia coli by bovine polymorphonuclear leucocytes. Res Vet Sci. 1982; 33(1):47-53. View

13.

Bramley A, DODD F . Reviews of the progress of dairy science: mastitis control--progress and prospects. J Dairy Res. 1984; 51(3):481-512. DOI: 10.1017/s0022029900023797. View

14.

HILL A . Pathogenicity of two strains of Streptococcus uberis infused into lactating and non-lactating bovine mammary glands. Res Vet Sci. 1988; 45(3):400-4. View

15.

Sutra L, Mendolia C, Rainard P, Poutrel B . Encapsulation of Staphylococcus aureus isolates from mastitic milk: relationship between capsular polysaccharide types 5 and 8 and colony morphology in serum-soft agar, clumping factor, teichoic acid, and protein A. J Clin Microbiol. 1990; 28(3):447-51. PMC: 269641. DOI: 10.1128/jcm.28.3.447-451.1990. View

16.

Leigh J, Field T, Williams M . Two strains of Streptococcus uberis, of differing ability to cause clinical mastitis, differ in their ability to resist some host defence factors. Res Vet Sci. 1990; 49(1):85-7. View

17.

Leigh J, Field T . Killing of Streptococcus uberis by bovine neutrophils following growth in chemically defined media. Vet Res Commun. 1991; 15(1):1-6. DOI: 10.1007/BF00497784. View

18.

Lancefield R . Current knowledge of type-specific M antigens of group A streptococci. J Immunol. 1962; 89:307-13. View

19.

Weissmann G, Keiser H, BERNHEIMER A . STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER. J Exp Med. 1963; 118:205-22. PMC: 2137708. DOI: 10.1084/jem.118.2.205. View

20.

Dossett J, Kronvall G, Williams Jr R, Quie P . Antiphagocytic effects of staphylococcal protein A. J Immunol. 1969; 103(6):1405-10. View