Evolutionary Genetics of the Drosophila Alcohol Dehydrogenase Gene-enzyme System

Overview

Journal Genetica

Specialties Cell Biology
Genetics

Date 1993 Jan 1

PMID 8163153

Citations 9

Authors

P W Heinstra

Affiliations

Soon will be listed here.

Abstract

Evolutionary genetics embodies a broad research area that ranges from the DNA level to studies of genetic aspects in populations. In all cases the purpose is to determine the impact of genetic variation on evolutionary change. The broad range of evolutionary genetics requires the involvement of a diverse group of researchers: molecular biologists, (population) geneticists, biochemists, physiologists, ecologists, ethologists and theorists, each of which has its own insights and interests. For example, biochemists are often not concerned with the physiological function of a protein (with respect to pH, substrates, temperature, etc.), while ecologists, in turn, are often not interested in the biochemical-physiological aspects underlying the traits they study. This review deals with several evolutionary aspects of the Drosophila alcohol dehydrogenase gene-enzyme system, and includes my own personal viewpoints. I have tried to condense and integrate the current knowledge in this field as it has developed since the comprehensive review by van Delden (1982). Details on specific issues may be gained from Sofer and Martin (1987), Sullivan, Atkinson and Starmer (1990); Chambers (1988, 1991); Geer, Miller and Heinstra (1991); and Winberg and McKinley-McKee (1992).

Citing Articles

A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm in .

Peterson S, Ahmad S Int J Mol Sci. 2024; 25(23).

PMID: 39684317 PMC: 11641815. DOI: 10.3390/ijms252312605.

Ethanol-guided behavior in Drosophila larvae.

Schumann I, Berger M, Nowag N, Schafer Y, Saumweber J, Scholz H Sci Rep. 2021; 11(1):12307.

PMID: 34112872 PMC: 8192949. DOI: 10.1038/s41598-021-91677-3.

Fitness effects but no temperature-mediated balancing selection at the polymorphic gene of .

Siddiq M, Thornton J Proc Natl Acad Sci U S A. 2019; 116(43):21634-21640.

PMID: 31594844 PMC: 6815130. DOI: 10.1073/pnas.1909216116.

A major role for noncoding regulatory mutations in the evolution of enzyme activity.

Loehlin D, Ames J, Vaccaro K, Carroll S Proc Natl Acad Sci U S A. 2019; 116(25):12383-12389.

PMID: 31152141 PMC: 6589674. DOI: 10.1073/pnas.1904071116.

Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.

Siddiq M, Loehlin D, Montooth K, Thornton J Nat Ecol Evol. 2017; 1(2):25.

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