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Host Cell Proteases Controlling Virus Pathogenicity

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Date 1994 Feb 1
PMID 8162439
Citations 218
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Abstract

The majority of viral glycoproteins that undergo post-translational proteolysis are cleaved by ubiquitous intracellular proteases; however, a minority are cleaved by secreted proteases available only in a few host systems. The interplay of viral glycoproteins and cellular proteases may have a pivotal role in the spread of infection, host range and pathogenicity.

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