Gelsolin is Localized in Neuronal Growth Cones

Overview

Journal Brain Res Dev Brain Res

Specialty Neurology

Date 1993 Dec 17

PMID 8149595

Citations 18

Authors

J Tanaka

M Kira

K Sobue

Affiliations

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Abstract

Gelsolin, a Ca(2+)-sensitive actin filament-severing protein, is involved in actin turnover. Immunocytochemical study with anti-gelsolin antibody revealed that the protein is localized in both filopodia and the body part of growth cones of differentiated PC12 cells with nerve growth factor (NGF) and of rat dorsal root ganglion neurons. Here, we identified gelsolin as one of the molecular bases for the Ca(2+)-dependent movement of growth cones.

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