Immunoblastic Sarcoma with Leukemic Blood Picture in the Terminal Stage of Mycosis Fungoides

Overview

Journal Virchows Arch A Pathol Anat Histol

Specialty Pathology

Date 1975 Dec 31

PMID 814706

Citations 3

Authors

E W Schwarze

P Ude

Affiliations

Soon will be listed here.

Abstract

A 76 year old man with mycosis fungoides developed an immunoblastic sarcoma and a leukemic blood picture in the final tumor stage after 6 years, in which the disease had clinically progressed in a typical manner. The results of histological and cytochemical studies of autopsy material are presented. Based on these findings and evidence of the T cell nature of mycosis fungoides, the immunoblastic sarcoma observed in the terminal stage of this case of mycosis fungoides might be of the rare T cell type.

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Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study.

Salhany K, Cousar J, Greer J, Casey T, FIELDS J, Collins R Am J Pathol. 1988; 132(2):265-77.

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Quantitative analysis of lymphoid cells in myocosis fungoides, Sézary's syndrome and parapsoriasis en plaques.

Schmoeckel C, Burg G, Braun-Falco O Arch Dermatol Res. 1979; 264(1):17-28.

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References

LUKES R, Collins R . New approaches to the classification of the lymphomata. Br J Cancer Suppl. 1975; 2:1-28. PMC: 2149570. View

CYR D, GEOKAS M, WORSLEY G . Mycosis fungoides. Hematologic findings and terminal course. Arch Dermatol. 1966; 94(5):558-73. DOI: 10.1001/archderm.94.5.558. View

Flandrin G, Brouet J . The Sezary cell: cytologic, cytochemical, and immunologic studies. Mayo Clin Proc. 1974; 49(8):575-83. View

Loffler H . [Cytological findings in the Sézary syndrome]. Verh Dtsch Ges Inn Med. 1972; 78:285-7. View

LUTZNER M, Hobbs J, Horvath P . Ultrastructure of abnormal cells in Sezary syndrome, mycosis fungoides, and parapsoriasis en plaque. Arch Dermatol. 1971; 103(4):375-86. DOI: 10.1001/archderm.103.4.375. View

Catovsky D . Letter: T-cell origin of acid-phosphatase-positive lymphoblasts. Lancet. 1975; 2(7929):327-8. DOI: 10.1016/s0140-6736(75)92767-1. View

LUTZNER M, JORDAN H . The ultrastructure of an abnormal cell in Sézary's syndrome. Blood. 1968; 31(6):719-26. View

Lennert K . Morphology and classification of malignant lymphomas and so-called reticuloses. Acta Neuropathol Suppl. 1975; Suppl 6:1-16. DOI: 10.1007/978-3-662-08456-4_1. View

Edelson R, LUTZNER M, Kirkpatrick C, Shevach E, Green I . Morphologic and functional properties of the atypical T lymphocytes of the Sezary syndrome. Mayo Clin Proc. 1974; 49(8):558-66. View

10.

Lennert K, STEIN H, Kaiserling E . Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer Suppl. 1975; 2:29-43. PMC: 2149614. View

11.

Block J, EDGCOMB J, Eisen A, VAN SCOTT E . Mycosis fungoides. Natural history and aspects of its relationship to other malignant lymphomas. Am J Med. 1963; 34:228-35. DOI: 10.1016/0002-9343(63)90056-1. View

12.

Biberfeld P . Morphogenesis in blood lymphocytes stimulated with phytohaemagglutinin (PHA). A light and electron microscopic study. Acta Pathol Microbiol Scand Suppl. 1971; 223:Suppl 223:1-70. View

13.

Epstein Jr E, Levin D, Croft Jr J, LUTZNER M . Mycosis fungoides. Survival, prognostic features, response to therapy, and autopsy findings. Medicine (Baltimore). 1972; 51(1):61-72. View

14.

Ding J, Adams P, Patison M, Cooper I . Thymic origin of abnormal lymphoid cells in Sézary syndrome. Cancer. 1975; 35(5):1325-32. DOI: 10.1002/1097-0142(197505)35:5<1325::aid-cncr2820350513>3.0.co;2-w. View

15.

Edelson R, Kirkpatrick C, Shevach E, Schein P, Smith R, Green I . Preferential cutaneous infiltration by neoplastic thymus-derived lymphocytes. Morphologic and functional studies. Ann Intern Med. 1974; 80(6):685-92. DOI: 10.7326/0003-4819-80-6-685. View

16.

SANDBANK M, Ben-Bassat M . Mycosis fungoides and Sezary's syndrome. Light and electron microscopic study before and after treatment. Isr J Med Sci. 1971; 7(11):1262-70. View

17.

Rappaport H, THOMAS L . Mycosis fungoides: the pathology of extracutaneous involvement. Cancer. 1974; 34(4):1198-229. DOI: 10.1002/1097-0142(197410)34:4<1198::aid-cncr2820340431>3.0.co;2-e. View

18.

Lennert K . [PATHOLOGIC ANATOMY OF RETICULOSES]. Krebsforsch Krebsbekampf. 1964; 30:48-67. View

19.

STEIN H, Kaiserling E, Lennert K . Evidence for B-cell origin of reticulum cell sarcoma. Virchows Arch A Pathol Anat Histol. 1974; 364(1):51-67. DOI: 10.1007/BF01230857. View

20.

DAMESHEK W . "Immunoblasts" and "immunocytes"--an attempt at a functional nomenclature. Blood. 1963; 21:243-5. View