Human Faecal Immunoglobulins in Healthy Infants and Children, and in Some with Diseases Affecting the Intestinal Tract or the Immune System

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1975 Nov 1

PMID 813931

Citations 15

Authors

B Haneberg

D AARSKOG

Affiliations

Soon will be listed here.

Abstract

IgA, IgG and IgM is faeces were quantified by single radial immunodiffusion using extracts of freeze-dried faeces. IgA in small specimens of faeces seemed to mirror the total amound of IgA secreted into the gut at the time of sampling. Presumptive normal values of faecal IgA concentrations in infants and children were established. Agglutinins to rabbit erythrocytes served as markers for the antibody activity. Infants and children just recovered from enteritis of probably infectious origin had higher concentrations of both IgA and agglutinins in faeces. Faeces from three out of five patients with ulcerative colitis in remission, contained IgG in markedly increased concentrations. Two patients with IgA deficiency had no detectable IgA in faeces, but had increased levels of faecal IgM which also agglutinated rabbit erythrocytes. Immunoglobulins were not demonstrated in faeces from three patients with agammaglobulinaemia. The findings indicate that faeces can be used for assay of immunoglobulins of the intestinal tract.

Citing Articles

Requirement of a Wnt5A-microbiota axis in the maintenance of gut B-cell repertoire and protection from infection.

Sengupta S, Sen M mSphere. 2024; 9(9):e0020424.

PMID: 39140737 PMC: 11423572. DOI: 10.1128/msphere.00204-24.

Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis.

Saha P, Mell B, Golonka R, Bovilla V, Abokor A, Mei X Hypertension. 2022; 79(10):2239-2249.

PMID: 35950503 PMC: 9458624. DOI: 10.1161/HYPERTENSIONAHA.122.19307.

Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem.

Leon E, Francino M Front Microbiol. 2022; 13:880484.

PMID: 35722300 PMC: 9203039. DOI: 10.3389/fmicb.2022.880484.

Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization.

Zhang B, Liu E, Gertie J, Joseph J, Xu L, Pinker E Sci Immunol. 2020; 5(47).

PMID: 32385053 PMC: 8518330. DOI: 10.1126/sciimmunol.aay2754.

Interactions between the Gut Microbiome and Mucosal Immunoglobulins A, M, and G in the Developing Infant Gut.

Janzon A, Goodrich J, Koren O, Waters J, Ley R mSystems. 2019; 4(6).

PMID: 31771976 PMC: 6880043. DOI: 10.1128/mSystems.00612-19.

References

Freter R, De S, Mondal A, Shrivastava D, SUNDERMAN Jr F . COPROANTIBODY AND SERUM ANTIBODY IN CHOLERA PATIENTS. J Infect Dis. 1965; 115:83-7. DOI: 10.1093/infdis/115.1.83. View

RULE A, Lawrence D, HAGER H, Hyslop Jr N, SHWACHMAN H . IgA: presence in meconium obtained from patients with cystic fibrosis. Pediatrics. 1971; 48(4):601-4. View

REED W, Williams Jr R . Intestinal immunoglobulins in shigellosis. Gastroenterology. 1971; 61(1):35-45. View

Brandtzaeg P, Fjellanger I, GJERULDSEN S . Immunoglobulin M: local synthesis and selective secretion in patients with immunoglobulin A deficiency. Science. 1968; 160(3829):789-91. DOI: 10.1126/science.160.3829.789. View

South M, COPPER M, Wollheim F, GOOD R . The IgA system. II. The clinical significance of IgA deficiency: studies in patients with agammaglobulinemia and ataxia-telangiectasia. Am J Med. 1968; 44(2):168-78. DOI: 10.1016/0002-9343(68)90148-4. View

Gelzayd E, KRAFT S, Fitch F, Kirsner J . Distribution of immunoglobulins in human rectal mucosa. II. Ulcerative colitis and abnormal mucosal control subjects. Gastroenterology. 1968; 54(3):341-7. View

CRABBE P, Heremans J . Lack of gamma A-immunoglobulin in serum of patients with steatorrhoea. Gut. 1966; 7(2):119-27. PMC: 1552348. DOI: 10.1136/gut.7.2.119. View

Shearman D, Parkin D, McClelland D . The demonstration and function of antibodies in the gastrointestinal tract. Gut. 1972; 13(6):483-99. PMC: 1412198. DOI: 10.1136/gut.13.6.483. View

Agus S, Falchuk Z, Sessoms C, Wyatt R, Dolin R . Increased jejunal IgA synthesis in vitro during acute infectious nonbacterial gastroenteritis. Am J Dig Dis. 1974; 19(2):127-31. DOI: 10.1007/BF01072622. View

10.

Haneberg B . Immunoglobulins in feces from infants fed human or bovine milk. Scand J Immunol. 1974; 3(2):191-7. DOI: 10.1111/j.1365-3083.1974.tb01247.x. View

11.

Savilahti E . IgA deficiency in children. Immunoglobulin-containing cells in the intestinal mucosa, immunoglobulins in secretions and serum IgA levels. Clin Exp Immunol. 1973; 13(3):395-406. PMC: 1553771. View

12.

Samson R, McClelland D, Shearman D . Studies on the quantitation of immunoglobulin in human intestinal secretions. Gut. 1973; 14(8):616-26. PMC: 1412759. DOI: 10.1136/gut.14.8.616. View

13.

Tomasi T, Grey H . Structure and function of immunoglobulin A. Prog Allergy. 1972; 16:81-213. View

14.

Haneberg B, TONDER O . Immunoglobulins and other serum proteins in feces from infants and children. Scand J Immunol. 1973; 2(4):375-83. DOI: 10.1111/j.1365-3083.1973.tb02046.x. View

15.

Haneberg B . Human milk immunoglobulins and agglutinins to rabbit erythrocytes. Int Arch Allergy Appl Immunol. 1974; 47(5):716-29. DOI: 10.1159/000231263. View

16.

Brandtzaeg P, Baklien K, Fausa O, Hoel P . Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology. 1974; 66(6):1123-36. View

17.

Haneberg B . Human fetal agglutinins to rabbit erythrocytes. Scand J Immunol. 1974; 3(1):71-6. DOI: 10.1111/j.1365-3083.1974.tb01234.x. View

18.

Panayotou P, Papadatos C, Papaevangelou G, Alexiou D, Skardoutsou A, Kourea E . Immunoglobulin A and M levels in premature infants with gastroenteritis. Arch Dis Child. 1971; 46(249):671-5. PMC: 1647855. DOI: 10.1136/adc.46.249.671. View

19.

ROULET D, von MURALT . [Antigen analytic research on amniotic fluid and meconium proteins. Contribution to the problem of immune globulin transmission from mother to child]. Schweiz Med Wochenschr. 1961; 91:74-9. View