Angiotensin Converting Enzyme in Renal Ontogeny: Hypothesis for Multiple Roles

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 1993 Dec 1

PMID 8130118

Citations 7

Authors

F F Jung

B Bouyounes

R Barrio

S S Tang

D Diamant

J R Ingelfinger

Affiliations

Soon will be listed here.

Abstract

Angiotensin converting enzyme (ACE) has multiple effects both as the enzyme which cleaves angiotensin II from angiotensin I and as that which breaks down bradykinin. The present study examines ACE mRNA and protein expression in the rat kidney during development. Changes in distribution and expression during development are consistent with suggestions that the renin angiotensin system is important in growth modulation, vascular development and regulation, and protein reabsorption.

Citing Articles

Renin-angiotensin system in mammalian kidney development.

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Angiotensin II stimulates in vitro branching morphogenesis of the isolated ureteric bud.

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The urinary activity of angiotensin-converting enzyme in preterm, full-term newborns, and children.

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