Effect of Age on Cell-mediated Immunity in Long-lived Mice

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1975 Mar 1

PMID 812622

Citations 13

Authors

S A Goodman

T Makinodan

Affiliations

Soon will be listed here.

Abstract

The cytolytic ability of sensitized spleen cells to kill allogeneic target cells in vitro, a correlate of cell-mediated immune activity, was assessed in aging long-lived hybrid mice. There was about a 4-fold decline with age, of which about 2-fold could be accounted for by the decrease in relative numbers of immunocompetent precursor cell units. The terminally differentiated progeny cells of antigen-stimulated precursor cells of old mice were as efficient in killing target cells as were those of precursor cells of young mice. Thus, it would appear that a decrease in the proliferative and transforming capacities of antigen-stimulated precursor cells of old mice can account for the other 2-fold decline with age in the cytolytic activity. Cytolytic activity may not be the limiting function in resistance to tumour formation. This was indicated by the observation that resistance to allogeneic tumor cell challenge declines with age by as much as 500-fold in mice, showing only a 4-fold decline in their cytolytic activity.

Citing Articles

Cellular and molecular aspects of immune system aging.

Doggett D, Chang M, Makinodan T, Strehler B Mol Cell Biochem. 1981; 37(3):137-56.

PMID: 7024781 DOI: 10.1007/BF02354883.

Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans.

Fernandes G, Gupta S J Clin Immunol. 1981; 1(3):141-8.

PMID: 6977553 DOI: 10.1007/BF00922755.

Aging and cellular defense mechanisms: age-related changes in resistance of mice to Listeria monocytogenes.

Patel P Infect Immun. 1981; 32(2):557-62.

PMID: 6788698 PMC: 351483. DOI: 10.1128/iai.32.2.557-562.1981.

Early biochemical events associated with lymphocyte activation in ageing. I. Evidence that Ca2+ dependent processes induced by PHA are impaired.

Kennes B, Hubert C, Brohee D, Neve P Immunology. 1981; 42(1):119-26.

PMID: 6780450 PMC: 1458208.

Different metastatic modes of malignant melanoma implanted in the ear of young and old mice.

Hirayama R, Sato K, Hirokawa K, Chang M, Mishima Y, Makinodan T Cancer Immunol Immunother. 1984; 18(3):209-14.

PMID: 6568876 PMC: 11041035. DOI: 10.1007/BF00205513.

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