Uteroglobin-like Antigen in the Male Genital Tract Secretions

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1975 Dec 29

PMID 812607

Citations 8

Authors

H M Beier

H Bohn

W Muller

Affiliations

Soon will be listed here.

Abstract

The secretion of the rabbit seminal vesicle has been investigated by morphological and biochemical means. Apical regions of seminal vesicle epithelial cells show highly active protein synthesizing and releasing organells. The secretory proteins released are analysed by disc-electrophoresis and three different immunological procedures. There is evidence for the presence of an uteroglobin-like antigen in seminal vesicle secretion. Comparison with seminal plasma indicated that the uteroglobin-like protein is also present in this fluid. The immunological and electrophoretical identity of rabbit uteroglobin, obtained from the uterus, with "male uteroglobin" is obvious, but molecular-biochemical and biological identity awaits further clarification. The demonstration of uteroglobin-like antigen in the male as in the female points towards new aspects in reproductive and contraceptive research.

Citing Articles

Recombinant bovine uteroglobin at 1.6 A resolution: a preliminary X-ray crystallographic analysis.

von der Decken V, Delbruck H, Herrler A, Beier H, Fischer R, Hoffmann K Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006; 61(Pt 5):499-502.

PMID: 16511079 PMC: 1952310. DOI: 10.1107/S1744309105011231.

Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

Peri A, Miele L, Mukherjee A J Clin Invest. 1993; 92(5):2099-109.

PMID: 8227325 PMC: 288387. DOI: 10.1172/JCI116810.

Uteroglobin gene expression in the rabbit uterus throughout gestation and in the fetal lung. Relationship between uteroglobin and eicosanoid levels in the developing fetal lung.

Peri A, Dubin N, Dhanireddy R, Mukherjee A J Clin Invest. 1995; 96(1):343-53.

PMID: 7615804 PMC: 185206. DOI: 10.1172/JCI118040.

Proteinase inhibitor identification in the uteroglobin fraction of rabbit uterine secretion.

Hackenberg R, Beier H Arch Gynecol. 1982; 231(4):289-97.

PMID: 7149780 DOI: 10.1007/BF02111727.

Immunocytochemical localization of uteroglobin in the genital tract of male rabbits.

El Etreby M, Beier H, Elger W, Mahrous A, Topert M Cell Tissue Res. 1983; 229(1):61-73.

PMID: 6339065 DOI: 10.1007/BF00217880.

References

FEIGELSON M, Kay E . Protein patterns of rabbit oviducal fluid. Biol Reprod. 1972; 6(2):244-52. DOI: 10.1093/biolreprod/6.2.244. View

Lavon U, BOURSNELL J . Characterization of boar seminal plasma, vesicular secretion and epididymal plasma proteins by gel disc electrophoresis and isoelectric focusing on polyacrylamide. J Reprod Fertil. 1971; 27(2):227-32. DOI: 10.1530/jrf.0.0270227. View

Schwick H . . Wilhelm Roux Arch Entwickl Mech Org. 2017; 156(3):283-343. DOI: 10.1007/BF01380607. View

BARNES G . The antigenic nature of male accessory glands of reproduction. Biol Reprod. 1972; 6(3):384-421. DOI: 10.1093/biolreprod/6.3.384. View

BOURSNELL J, Johnson P, Zamora J . An electrophoretic and ultracentrifugal study of boar seminal plasma. Biochim Biophys Acta. 1962; 63:374-81. DOI: 10.1016/0006-3002(62)90101-4. View

Beier H . Oviducal and uterine fluids. J Reprod Fertil. 1974; 37(1):221-37. DOI: 10.1530/jrf.0.0370221. View

Kirchner C . [Studies of uterine specific glycoproteins during early pregnancy of the rabbitOryctolagus cuniculus]. Wilhelm Roux Arch Entwickl Mech Org. 2017; 164(2):97-133. DOI: 10.1007/BF00581995. View

Setchell B . Secretions of the testis and epididymis. J Reprod Fertil. 1974; 37(1):165-77. DOI: 10.1530/jrf.0.0370165. View

Beier H . Hormonal stimulation of protease inhibitor activity in endometrial secretion during early pregnancy. Acta Endocrinol (Copenh). 1970; 63(1):141-9. DOI: 10.1530/acta.0.0630141. View

10.

Mann T . Secretory function of the prostate, seminal vesicle and other male accessory organs of reproduction. J Reprod Fertil. 1974; 37(1):179-88. DOI: 10.1530/jrf.0.0370179. View

11.

Beier H, KUHNEL W . Pseudopregnancy in the rabbit after stimulation by human chorionic gonadotropin. Horm Res. 1973; 4(1):1-27. DOI: 10.1159/000178286. View

12.

Beier H, KUHNEL W . [Morphological and biochemical studies on the secretion of seminal vesicles]. Verh Anat Ges. 1974; 68:231-45. View

13.

Davies D, Hall G, Hibbitt G, Moore H . The removal of the seminal vesicles from the boar and the effects on the semen characteristics. J Reprod Fertil. 1975; 43(2):305-12. DOI: 10.1530/jrf.0.0430305. View

14.

Lavon U, Briggs P, BOURSNELL J . Electrophoresis of protein fractions from boar seminal plasma, vesicular secretion and epididymal plasma. J Reprod Fertil. 1973; 33(1):39-51. DOI: 10.1530/jrf.0.0330039. View

15.

Noske I, FEIGELSON M . Immunological evidence of uteroglobin (blastokinin) in the male reproductive tract and in nonreproductive ductal tissues and their secretions. Biol Reprod. 1976; 15(5):704-13. DOI: 10.1095/biolreprod15.5.704. View

16.

Beier H, Maurer R . Uteroglobin and other proteins in rabbit blastocyst fluid after development in vivo and in vitro. Cell Tissue Res. 1975; 159(1):1-10. DOI: 10.1007/BF00231990. View

17.

Beier H, Beier-Hellwig K . Specific secretory protein of the female genital tract. Acta Endocrinol Suppl (Copenh). 1973; 180:404-25. DOI: 10.1530/acta.0.074s404. View

18.

Tauber P, Zaneveld L, Propping D, SCHUMACHER G . Components of human split ejaculates. I. Spermatozoa, fructose, immunoglobulins, albumin, lactoferrin, transferrin and other plasma proteins. J Reprod Fertil. 1975; 43(2):249-67. DOI: 10.1530/jrf.0.0430249. View

19.

Hunter A . Differentiation of rabbit sperm antigens from those of seminal plasma. J Reprod Fertil. 1969; 20(3):413-8. DOI: 10.1530/jrf.0.0200413. View

20.

KUHNEL W, Beier H . [Morphology and cytochemistry of the Harderian gland of Anatidae (author's transl)]. Z Zellforsch Mikrosk Anat. 1973; 141(2):255-83. View