Exposure of Workers to a Mixture of Toluene and Xylenes. II. Effects

Overview

Journal Occup Environ Med

Specialties Environmental Health
Occupational Medicine

Date 1994 Jan 1

PMID 8124463

Citations 5

Authors

Z Chen

S J Liu

S X Cai

Y M Yao

H Yin

H Ukai

Y Uchida

H Nakatsuka

T Watanabe

M Ikeda

Affiliations

Soon will be listed here.

Abstract

The health effects of exposure to a mixture of toluene and xylene isomers was studied on the fourth or fifth days of a working week in factories in China. The study population comprised 233 subjects (122 men and 111 women), who were exposed to the time weighted geometric mean (maximum) concentrations of toluene (3 (203) ppm) and xylenes (4 (103) ppm). For comparison, 241 non-exposed controls (116 men and 125 women) were recruited from the same regions. The prevalence of some subjective symptoms significantly increased in the exposed population, and the symptom profiles were similar to those found after exposure to toluene or xylenes alone. Haematology and serum biochemistry did not show notable changes. It seems reasonable to conclude that the effects of the toxicities of toluene and xylenes in combination are additive.

Citing Articles

Health risk assessment of volatile organic compounds exposure near Daegu dyeing industrial complex in South Korea.

Shuai J, Kim S, Ryu H, Park J, Lee C, Kim G BMC Public Health. 2018; 18(1):528.

PMID: 29678134 PMC: 5910572. DOI: 10.1186/s12889-018-5454-1.

Neuropsychological Symptoms among Workers Exposed to Toluene and Xylene in Two Paint Manufacturing Factories in Eastern Thailand.

Thetkathuek A, Jaidee W, Saowakhontha S, Ekburanawat W Adv Prev Med. 2015; 2015:183728.

PMID: 26290757 PMC: 4531158. DOI: 10.1155/2015/183728.

Effects of permissible maximum-contamination levels of VOC mixture in water on total DNA, antioxidant gene expression, and sequences of ribosomal DNA of Drosophila melanogaster.

Doganlar O, Doganlar Z, Tabakcioglu K Environ Sci Pollut Res Int. 2015; 22(20):15610-20.

PMID: 26018283 DOI: 10.1007/s11356-015-4741-y.

A study on neurobehavioral performance of workers occupationally exposed to solvent in synthetic resin manufacturing.

Saha A, Tripathi S Toxicol Int. 2015; 21(3):264-8.

PMID: 25948964 PMC: 4413408. DOI: 10.4103/0971-6580.155346.

Subtle increase in leukocyte counts in association with drinking and smoking habits.

Inoue O, Seiji K, Takahashi M, Kudo K, Nakatsuka H, Watanabe T Int Arch Occup Environ Health. 1995; 66(6):383-8.

PMID: 7782121 DOI: 10.1007/BF00383144.

References

Ikeda M, Kumai M, Aksoy M . Application of carbon felt dosimetry to field studies distant from analytical laboratory. Ind Health. 1984; 22(1):53-7. DOI: 10.2486/indhealth.22.53. View

Kasahara M, Ikeda M . Spontaneous desorption of organic solvents from carbon cloth. Ind Health. 1987; 25(2):73-81. DOI: 10.2486/indhealth.25.73. View

Yin S, Li G, Hu Y, Zhang X, Jin C, Inoue O . Symptoms and signs of workers exposed to benzene, toluene or the combination. Ind Health. 1987; 25(3):113-30. DOI: 10.2486/indhealth.25.113. View

Jonai H, Sato M . Exposure indices for painters exposed to toluene and xylene at low concentrations. Ind Health. 1988; 26(3):197-202. DOI: 10.2486/indhealth.26.197. View

Sakai T, Takeuchi Y, Ikeya Y, Araki T, Ushio K . [Method for simultaneous determination of six metabolites of toluene, xylene and ethylbenzene, and its application to exposure monitoring of workers in a printing factory with gravure machines]. Sangyo Igaku. 1989; 31(1):9-16. DOI: 10.1539/joh1959.31.9. View

Hajimiragha H, Ewers U, Brockhaus A, Boettger A . Levels of benzene and other volatile aromatic compounds in the blood of non-smokers and smokers. Int Arch Occup Environ Health. 1989; 61(8):513-8. DOI: 10.1007/BF00683121. View

Seedorff L, Olsen E . Exposure to organic solvents--I. A survey on the use of solvents. Ann Occup Hyg. 1990; 34(4):371-8. DOI: 10.1093/annhyg/34.4.371. View

Chen J, Wang J, Jang J, Chen Y . Exposure to mixtures of solvents among paint workers and biochemical alterations of liver function. Br J Ind Med. 1991; 48(10):696-701. PMC: 1012063. DOI: 10.1136/oem.48.10.696. View

Chan C, Spengler J, Ozkaynak H, Lefkopoulou M . Commuter exposures to VOCs in Boston, Massachusetts. J Air Waste Manage Assoc. 1991; 41(12):1594-600. DOI: 10.1080/10473289.1991.10466955. View

10.

Liu S, Qu Q, Xu X, Liu Y, Yin S, Takeuchi Y . Toluene vapor exposure and urinary excretion of hippuric acid among workers in China. Am J Ind Med. 1992; 22(3):313-23. DOI: 10.1002/ajim.4700220305. View

11.

Ukai H, Watanabe T, Nakatsuka H, Satoh T, Liu S, Qiao X . Dose-dependent increase in subjective symptoms among toluene-exposed workers. Environ Res. 1993; 60(2):274-89. DOI: 10.1006/enrs.1993.1037. View

12.

Uchida Y, Nakatsuka H, Ukai H, Watanabe T, Liu Y, Huang M . Symptoms and signs in workers exposed predominantly to xylenes. Int Arch Occup Environ Health. 1993; 64(8):597-605. DOI: 10.1007/BF00517707. View

13.

Huang M, Jin C, Liu Y, Li B, Qu Q, Uchida Y . Exposure of workers to a mixture of toluene and xylenes. I. Metabolism. Occup Environ Med. 1994; 51(1):42-6. PMC: 1127899. DOI: 10.1136/oem.51.1.42. View

14.

Ogata M, Takatsuka Y, Tomokuni K . Excretion of hippuric acid and m- or p-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylene in an exposure chamber and in workshops, with specific reference to repeated exposures. Br J Ind Med. 1971; 28(4):382-5. PMC: 1009333. DOI: 10.1136/oem.28.4.382. View

15.

Hirayama T, Ikeda M . Applicability of activated carbon felt to the dosimetry of solvent vapor mixture. Am Ind Hyg Assoc J. 1979; 40(12):1091-6. DOI: 10.1080/15298667991430749. View

16.

Kurppa K, Husman K . Car painters' exposure to a mixture of organic solvents. Serum activities of liver enzymes. Scand J Work Environ Health. 1982; 8(2):137-40. DOI: 10.5271/sjweh.2491. View

17.

Iregren A . Effects on psychological test performance of workers exposed to a single solvent (toluene)--a comparison with effects of exposure to a mixture of organic solvents. Neurobehav Toxicol Teratol. 1982; 4(6):695-701. View

18.

Inoue T, Takeuchi Y, Hisanaga N, Ono Y, Iwata M, Ogata M . A nationwide survey on organic solvent components in various solvent products: Part 1. Homogeneous products such as thinners, degreasers and reagents. Ind Health. 1983; 21(3):175-83. DOI: 10.2486/indhealth.21.175. View

19.

Kumai M, Koizumi A, Saito K, Sakurai H, Inoue T, Takeuchi Y . A nationwide survey on organic solvent components in various solvent products: Part 2. Heterogeneous products such as paints, inks and adhesives. Ind Health. 1983; 21(3):185-97. DOI: 10.2486/indhealth.21.185. View