Experimental Models of Complete Heart Block

Overview

Journal Basic Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 1975 Jul 1

PMID 811214

Authors

E K Weir

I F McMurtry

R F GROVER

Affiliations

Soon will be listed here.

Abstract

Methods of creating experimental complete heart block developed since 1883 are reviewed in detail. The three most commonly used techniques at present are: (I) Thoracotomy, atriotomy and ligation of the A-V bundle. (II) Thoracotomy and injection of a chemical into the A-V node or bundle. (III) Injection of a chemical through a transvenous catheter into the node or bundle. The results in different species, complications, and variations in procedure are discussed. The bibliography provides a comprehensive index of work performed in animals with experimental complete heart block. We produced complete heart block in sixteen pigs but subsequently eleven died during Stokes-Adams attacks. Pigs have not been used previously as models of heart block for experimental purposes and prophylactic pacing appears mandatory in this species.

References

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