Neisseria Gonorrhoeae and Neisseria Meningitidis: Extracellular Enzyme Cleaves Human Immunoglobulin A

Overview

Journal Science

Specialty Science

Date 1975 Dec 12

PMID 810892

Citations 94

Authors

A G Plaut

J V Gilbert

M S Artenstein

J D Capra

Affiliations

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Abstract

The gonococcus and meningococcus, which infect human mucosal surfaces, elaborate a highly specific proteolytic enzyme which cleaves the immunoglobulin A1 subclass of the principal mucosal antibody, immunoglobulin A (IgA). The susceptible Pro-Thr bond lies in a unique region of the IgA heavy chain; the IgA2 subclass, lacking this peptide bond, is enzyme resistant.

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