Comparison of Three Rocky Mountain Spotted Fever Vaccines

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1975 Oct 1

PMID 810494

Citations 11

Authors

R H Kenyon

L S Sammons

C E Pedersen Jr

Affiliations

Soon will be listed here.

Abstract

Growth of Rocky Mountain spotted fever (RMSF) rickettsiae in duck embryo cell (DEC) cultures and chicken embryo cell (CEC) cultures was evaluated. Experimental lots of duck embryo cell- and chicken embryo cell-grown Rocky Mountain spotted fever vaccines and a commercial lot of yolk sac-grown vaccine were compared for protective efficacy in rhesus monkeys. Incidence and magnitude of antibody response, febrile response, and rickettsemia, as well as incidence of fatalities, suggested that both cell culture-derived vaccines were more immunogenic than the yolk sac-grown vaccine.

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