CCKB Receptor Activation Reduces Glutamate-induced Depolarization in Slices of Rat Cerebral Cortex

Overview

Journal J Neural Transm Gen Sect

Specialties Neurology
Physiology

Date 1993 Jan 1

PMID 8103993

Citations 2

Authors

J Harro

P Westerling

L Oreland

Affiliations

Soon will be listed here.

Abstract

Recent studies on cell cultures have indicated that the neuropeptide cholecystokinin (CCK) can prevent glutamate-induced cytotoxicity. In a preparation of rat cortical tissue placed into a two-compartment bath, the cortical tissue could be depolarized, relative to the corpus callosum, by superfusions of KCl or glutamate (1.25-10 mM). Caerulein (1-100 nM), a CCK receptor agonist, caused a rightward shift of the glutamate dose-response curve. The effect of caerulein was abolished by adding L365,260 (1 microM), a selective CCKB receptor antagonist. These findings suggest that CCK may be a physiological antagonist of glutamate-mediated neurotransmission in the rat brain.

Citing Articles

Cholecystokinin action on layer 6b neurons in somatosensory cortex.

Chung L, Moore S, Cox C Brain Res. 2009; 1282:10-9.

PMID: 19497313 PMC: 2738607. DOI: 10.1016/j.brainres.2009.05.061.

Cholecystokinin peptides and receptor binding in Alzheimer's disease.

Lofberg C, Harro J, Gottfries C, Oreland L J Neural Transm (Vienna). 1996; 103(7):851-60.

PMID: 8872869 DOI: 10.1007/BF01273363.

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