Serum IgE Levels and Reaginic-type Skin Reactions in Sarcoidosis

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1975 Aug 1

PMID 810284

Citations 2

Authors

T YAGURA

M Shimizu

Y Yamamura

T Tachibana

Affiliations

Soon will be listed here.

Abstract

Immunoglobulin E (IgE) levels in sera of eighty-four patients with sarcoidosis and fifty-one apparently healthy controls were measured by means of a radioimmunosorbent test (RIST). A significant decrease in IgE level was commonly seen in patients with sarcoidosis. In some patients, a typical isolated IgE deficiency was noted. In a group of patients with significantly low serum IgE levels, reduced immune responsiveness affecting the IgE class was suggested from the study on reaginic-type skin reactions. The implication of these findings with respect to the immunology and etiology of sarcoidosis is discussed.

Citing Articles

Biochemical findings in sarcoidosis.

Studdy P, Bird R, Neville E, James D J Clin Pathol. 1980; 33(6):528-33.

PMID: 6249857 PMC: 1146136. DOI: 10.1136/jcp.33.6.528.

Immune function in sarcoidosis. Studies on delayed hypersensitivity, B and T lymphocytes, serum immunoglobulins and serum complement components.

Tannenbaum H, Rocklin R, Schur P, Sheffer A Clin Exp Immunol. 1976; 26(3):511-9.

PMID: 795577 PMC: 1540971.

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