Midbrain 6-hydroxydopamine Lesions Modulate Blink Reflex Excitability

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1993 Jan 1

PMID 8101493

Citations 25

Authors

M A Basso

R E Strecker

C Evinger

Affiliations

Soon will be listed here.

Abstract

The blink reflex abnormalities present in the 6 hydroxydopamine (6-OHDA) lesioned rat model of parkinsonism mimicked those of the human with Parkinson's disease. In alert rats, we monitored the long and short latency components of the orbicularis oculi electromyographic (OOemg) response evoked by electrical stimulation of the supraorbital branch of the trigeminal nerve (SO). Two paradigms, habituation and double pulse, provided a measure of blink reflex excitability. In normal rats, repeated stimulation of the SO produced habituation of the R2 component of the blink. In the double pulse paradigm, presentation of two identical SO stimuli resulted in a reduced or suppressed OOemg response to the second stimulus relative to the first. In rats with complete, unilateral lesions of midbrain dopamine neurons, repeated SO stimulation produced facilitation rather than habituation of the R2 component of the blink reflex. This facilitation occurred only with the eyelid contralateral to the lesion. In the double pulse paradigm, the lesioned rats showed increased excitability rather than suppression. This effect occurred bilaterally, although the increased excitability was strongest contralateral to the lesion. Rats with partial lesions of midbrain dopamine neurons exhibited qualitatively similar, but less pronounced blink reflex abnormalities. The R1 component of the blink reflex was unaffected by either the complete or partial lesions. Thus, modification of the blink reflex by 6-OHDA lesions provides a reproducible parkinsonian-like symptom which is amenable to investigations of increases in reflex excitability.

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References

White O, Saint-Cyr J, Tomlinson R, Sharpe J . Ocular motor deficits in Parkinson's disease. III. Coordination of eye and head movements. Brain. 1988; 111 ( Pt 1):115-29. DOI: 10.1093/brain/111.1.115. View

Pearce J, Aziz H, Gallagher J . Primitive reflex activity in primary and symptomatic Parkinsonism. J Neurol Neurosurg Psychiatry. 1968; 31(5):501-8. PMC: 496408. DOI: 10.1136/jnnp.31.5.501. View

Messina C, Di Rosa A, Tomasello F . Habituation of blink reflexes in parkinsonian patients under levodopa and amantadine treatment. J Neurol Sci. 1972; 17(2):141-8. DOI: 10.1016/0022-510x(72)90136-0. View

Caligiuri M, Abbs J . Response properties of the perioral reflex in Parkinson's disease. Exp Neurol. 1987; 98(3):563-72. DOI: 10.1016/0014-4886(87)90265-2. View

Brundin P, Nilsson O, Strecker R, Lindvall O, ASTEDT B, Bjorklund A . Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp Brain Res. 1986; 65(1):235-40. DOI: 10.1007/BF00243848. View

Caraceni T, Avanzini G, Spreafico R, Negri S, Broggi G, Girotti F . Study of the excitability cycle of the blink reflex in Huntington's chorea. Eur Neurol. 1976; 14(6):465-72. DOI: 10.1159/000114774. View

Penders C, Delwaide P . Blink reflex studies in patients with Parkinsonism before and during therapy. J Neurol Neurosurg Psychiatry. 1971; 34(6):674-8. PMC: 1083500. DOI: 10.1136/jnnp.34.6.674. View

Mink J, Thach W . Basal ganglia motor control. III. Pallidal ablation: normal reaction time, muscle cocontraction, and slow movement. J Neurophysiol. 1991; 65(2):330-51. DOI: 10.1152/jn.1991.65.2.330. View

Agostino R, Berardelli A, Cruccu G, Pauletti G, Stocchi F, Manfredi M . Correlation between facial involuntary movements and abnormalities of blink and corneal reflexes in Huntington's chorea. Mov Disord. 1988; 3(4):281-9. DOI: 10.1002/mds.870030401. View

10.

Dengler R, Kossev A, STRUPPLER A . Unilateral reduction of the early and late blink reflex component in hemiparkinson syndrome. Electroencephalogr Clin Neurophysiol. 1982; 54(6):689-98. DOI: 10.1016/0013-4694(82)90123-7. View

11.

Evinger C, Basso M, Manning K, Sibony P, Pellegrini J, Horn A . A role for the basal ganglia in nicotinic modulation of the blink reflex. Exp Brain Res. 1993; 92(3):507-15. DOI: 10.1007/BF00229040. View

12.

Bollen E, Arts R, Roos R, van der Velde E, Buruma O . Brainstem reflexes and brainstem auditory evoked responses in Huntington's chorea. J Neurol Neurosurg Psychiatry. 1986; 49(3):313-5. PMC: 1028732. DOI: 10.1136/jnnp.49.3.313. View

13.

Matsumoto H, Noro H, Kaneshige Y, Chiba S, Miyano N, Motoi Y . A correlation study between blink reflex habituation and clinical state in patients with Parkinson's disease. J Neurol Sci. 1992; 107(2):155-9. DOI: 10.1016/0022-510x(92)90283-q. View

14.

Kimura J . Disorder of interneurons in Parkinsonism. The orbicularis oculi reflex to paired stimuli. Brain. 1973; 96(1):87-96. DOI: 10.1093/brain/96.1.87. View

15.

Fuhr P, Zeffiro T, Hallett M . Cutaneous reflexes in Parkinson's disease. Muscle Nerve. 1992; 15(6):733-9. DOI: 10.1002/mus.880150618. View

16.

Esteban A, Gimenez-Roldan S . Blink reflex in Huntingon's chorea and Parkinson's disease. Acta Neurol Scand. 1975; 52(2):145-57. DOI: 10.1111/j.1600-0404.1975.tb05768.x. View

17.

Ungerstedt U, Arbuthnott G . Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res. 1970; 24(3):485-93. DOI: 10.1016/0006-8993(70)90187-3. View

18.

Sanes J . Voluntary movement and excitability of cutaneous eyeblink reflexes. Psychophysiology. 1984; 21(6):653-64. DOI: 10.1111/j.1469-8986.1984.tb00253.x. View

19.

Raffaele R, Emery P, Palmeri A, Ricca G, Perciavalle V . Influences of dopaminergic systems on the blink reflex. Ital J Neurol Sci. 1988; 9(4):351-4. DOI: 10.1007/BF02333998. View

20.

Berardelli A, Cruccu G, Manfredi M, Rothwell J, Day B, Marsden C . The corneal reflex and the R2 component of the blink reflex. Neurology. 1985; 35(6):797-801. DOI: 10.1212/wnl.35.6.797. View