The Effect of Vpu on HIV-1-induced Syncytia Formation

Overview

Journal J Acquir Immune Defic Syndr (1988)

Specialty Infectious Diseases

Date 1993 Feb 1

PMID 8094456

Citations 20

Authors

X J Yao

S Garzon

F Boisvert

W A Haseltine

E A Cohen

Affiliations

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Abstract

To investigate the role of vpu in the cytopathicity of human immunodeficiency type 1 (HIV-1), the MT4 CD4+ T-cell line was infected with viruses that were isogenic except for their ability to produce the vpu protein. The experiments described here demonstrate that expression of vpu reduces HIV-1 cytopathic effects by decreasing the rate of syncytia formation. By reducing the concentration of gp 120 at the cell surface, vpu limits cell killing by syncytia formation.

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