The Ancient Regulatory-protein Family of WD-repeat Proteins

Overview

Journal Nature

Specialty Science

Date 1994 Sep 22

PMID 8090199

Citations 501

Authors

E J Neer

C J Schmidt

R Nambudripad

T F Smith

Affiliations

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Abstract

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

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